Division of Gene Structure and Function Division of Gene Regulation and Signal Transduction
Division of Developmental Biology Division of Pathophysiogy
Division of Functional Genomics & Systems Medicine Division of Gene Therapy
Division of Translational Research  
Division of Developmental Biology
概要 Research Summary

ES cells are known to differentiate into any types of cells including germ cells in vivo and in vitro. ES cells have many other prominent features discriminating from other tissue culture cells such as the ability for propagating permanently. Our primary purpose is to elucidate these ES cell-specific biological properties in molecular levels. The iPS cells have essentially the same characteristics of ES cells. The iPS cells are more superior than ES cells in some extent about ethics and tissue rejection problems. However, iPS cells have a specific disadvantage compared to ES cells that iPS cells are sometimes more prone to produce tumors. Therefore, one of our main purposes is to elevate safety level of iPS cells to the level of ES cells.

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スタッフ Staff
Professor Akihiko Okuda
Instructor Masataka Hirasaki, Ayumu Suzuki
Post doctor Atsushi Ueda
Resercher Madoka Kage
テーマ Research Projects
Molecular basis of pluripotent properties of ES cells
Molecular basis of tumorigenic properties of ES cells
Understanding of common properties of multiple types of stem cells
Elevation of safety level of iPS cells for clinic use
文献 Selected Publications
Katano M, Ema M, Nakachi Y, Mizuno Y, Hirasaki M, Suzuki A, Ueda A, Nishimoto M, Takahashi S, Okazaki Y, Okuda A. Forced expression of Nanog or Esrrb preserves the ESC status in the absence of nucleostemin expression. Stem Cell 33:1089-1101, (2015)
[PMID: 25522312]
Hishida T, Nakachi Y, Mizuno Y, Katano M, Okazaki Y, Ema M, Takahashi S, Hirasaki M, Suzuki A, Ueda A, Nishimoto M, Hishida-Nozaki Y, Vazquez-Ferrer E, Sancho-Martinez I, Izpisua Belmonte JC Okuda A. Functional crosstalk between Myc and PI3K signaling for supporting unlimited self-renewal of embryonic stem cells. Stem Cells33:713-725, (2015)
[PMID: 25385436]
Kamon M, Katano M, Hiraki K, Hishida T, Nakachi Y, Mizuno Y, Okazaki Y, Suzuki A, Hirasaki M, Ueda A, Nishimoto M, Kato H, Okuda A. Identification of Ccr4-Not complex components as regulators of transition from partial to genuine induced pluripotent stem cells. Stem Cells Dev 23:2170-2179, (2014)
[PMID: 24200330]
Hirasaki M, Hiraki-Kamon K, Kamon M, Suzuki A, Katano M, Nishimoto M, Okuda A. Striking similarity in the gene expression levels of individual Myc module members among ESCs, EpiSCs, and partial iPSCs. PLoS One e83769, (2013)
[PMID: 24386274]
Nishimoto M, Katano M, Yamagishi T, Hishida T, Kamon M, Suzuki A, Hirasaki M, NabeshimaYok, Nabeshima Yo-i, Katsura Y, Satta Y, Deakin JE, Graves JA, Kuroki Y, Ono R, Ishino F, Ema M, Takahashi S, Kato H, Okuda, A. In vivo function and evolution of the eutherian-specific pluripotency marker UTF1. PLoS One 8, e68119, (2013)
[PMID: 23874519]
Hikichi T, Matoba R, Ikeda T, Watanabe A, Yamamoto T, Yoshitake S, Tamura-Nakano M, Kimura T, Kamon M, Shimura M, Kawakami K, Okuda A, Okochi H, Inoue T, Suzuki A, Masui S. Transcription factors interfering with dedifferentiation induce cell type-specific transcriptional profiles. Proc Natl Acad Sci USA 110: 6412-6417, (2013)
[PMID: 23550161]
Maeda I, Okamura D, Tokitake Y, Ikeda M, Kawaguchi H, Mise N, Abe K, Noce T, Okuda A, Matsui Y. Max was identified as a repressor of germ-cell related gene expression in mouse embryonic stem cells. Nat. Commun 4: 1754, (2013)
[PMID: 23612295]
Hishida T, Nozaki Y, Nakachi Y, Mizuno Y, Iseki H, Katano M, Kamon M, Hirasaki M, Nishimoto M, Okazaki Y, Okuda A. Sirt1, p53 and p38MAPK are crucial regulators of detrimental phenotypes of ESCs with Max expression ablation. Stem Cells 30:1634-1644, (2012)
[PMID: 22696478]
Mariani J, Favaro R, Lancini C, Vaccari G, Ferri ALM, Bertolini J, Tonoli D, Latorre E, Caccia R, Ronchi A, Ottolenghi S, Miyagi S, Okuda A, Zappavigna V, Nicolis, SK. Emx2 is a dose-dependent negative regulator of Sox2 telencephalic enhancers. Nucleic Acids Res40: 6461-6476, (2012)
[PMID: 22495934]
Hishida T, Nozaki Y, Nakachi Y, Mizuno Y, Okazaki Y, Ema M, Takahashi S, Nishimoto M, Okuda A. Indefinite self-renewal of ESCs through Myc/Max transcriptional complex-independent mechanisms. Stem Cell 9: 37-49, (2011)
[PMID: 21726832]
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