 |
 |
Research Summary |
|
|
Although human genome sequence has completed in April 2003, the whole gene annotation and functional annotation of each gene is yet to be done. In our laboratory we are focusing more on the functional genomics based on the genome-wide approach combined with genetic approach. We are also targeting on a research of gene network and pathological network of diseased conditions by analyzing the genome-wide data derived from many model organisms using bioinformatics. By using a comparative genomics approach, we will try to understand the pathophysiological condition and to find a cure for common diseases. We are hoping to bridge the gap between basic science and clinical medicine.
|
|
Figure 1. |
| |
|
Figure 2. |
| |
|
 |
Staff |
|
| Professor |
Yasushi Okazaki |
| Assistant Professor |
Masahito Matsumoto |
| Instructor |
Yosuke Mizuno |
| Assistant |
Yukiko Yatsuka |
| Project Researcher |
Hiroyoshi Iseki,Yoshimi Tokuzawa,Izumi Sugahara |
| Post doctor |
Yoshihito Kishita |
| Graduate Student |
Shunsuke Tamaru, Hideno Tochigi |
| Project Technician |
Noriko Matsutani |
| Project Technical Assistant |
Chiharu Shimizu, Michiko Ishida |
| Visiting Professor |
Tatsuo Suda |
| Visiting Associate Professor |
Hideo Toyoshima |
| Researcher |
Hiroshi Yamaguchi, Tsuyoshi Sato |
|
 |
Research Projects |
|
Our main target is the identification of causative genes for common diseases such as metabolic syndrome, diabetes mellitus, and ischemic disease and finding molecules that might be used for therapeutic target by understanding the molecular mechanism underlying these diseases.
|
1) |
Understanding of pathological gene network and genetic factors causative of common diseases or multifactorial diseases (metabolic syndrome, diabetes mellitus, osteoporosis etc) |
|
1-1) |
Verifying the cross talk between lipid and bone metabolism using newly established pluripotent mesenchymal cell line (Fig1, Fig2) |
|
1-2) |
Genome wide RNAi phenotypic screening of C. elegans metabolic disturbance in the search for human disease genes |
| |
1-3) |
Identification of causative disease genes of mice using genetic approach combined with DNA microarray. |
2) |
Translational research including clinical diagnosis, tailor-made therapy, identification of novel secretary proteins etc |
3) |
Comparative Genomics Research |
| |
- Computational analysis of transcriptional regulatory element of nuclear receptors over species |
|
 |
Selected Publications |
|
1) |
Mizuno Y, Yagi K, Tokuzawa Y, Kanesaki-Yatsuka Y, Suda T, Katagiri T, Fukuda T, Maruyama M, Okuda A, Amemiya T, Kondoh Y, Tashiro H, Okazaki Y. miR-125b inhibits osteoblastic differentiation by down-regulation of cell proliferation. Biochem. Biophys. Res. Commun. 368:267-72 (2008)
[PMID: 18230348] |
2) |
Yamamoto K, Ninomiya Y, Iseki M, Nakachi Y, Kanesaki-Yatsuka Y, Yamanoue Y, Itoh T, Nishii Y, Petrovsky N, Okazaki Y. 4-Hydroxydocosahexaenoic acid, a potent peroxisome proliferator-activated receptor γ agonist alleviates the symptoms of DSS-induced colitis. Biochem. Biophys. Res. Commun. 367 : 566-72 (2008)
[PMID: 18191038] |
3) |
Arai S, Matsushita A, Du K, Yagi K, Okazaki Y, Kurokawa R. Novel homeodomain-interacting protein kinase family member, HIPK4, phosphorylates human p53 at serine 9. FEBS Letters. 581:5649-57(2007).
[PMID: 18022393] |
4) |
Otani K, Hiyama K, Satoh K, Shimamoto T, Mohamad D, Andoh M, Tonda T, Kohda M, Okazaki Y, Nishiyama M, Hiyama E and Ohtaki M. A mathematical model for affymetrix genechip probe level data. JP Journal of Biostatistics. 1(3) : 283-306 (2007) |
5) |
Ijichi N, Ikeda K, Horie-Inoue K, Yagi K, Okazaki Y, Inoue S. Estrogen-related receptor α modulates the expression of adipogenesis-related genes during adipocyte differentiation. Biochem. Biophys. Res. Commun. 358: 813-8 (2007)
[PMID: 17512501] |
6) |
Sugahara T, Yamashita Y, Shinomi M, Banri Y, Iseki H, Takeda A, Okazaki Y, Hayashizaki Y, Kawai K, Suemizu H and Andoh T. Isolation of a novel gene, mSVS-1/SUSD2, reversing tumorigenic phenotypes of cancer cells in vitro. Cancer Science. 98(6): 900-8. (2007)
[PMID: 17428258] |
7) |
Sugahara T, Yamashita Y, Shinomi M, Isobe Y, Yamanoha B, Iseki H, Takeda A, Okazaki Y, Kawai K, Suemizu H and Andoh T. von Willebrand factor type D domain mutant of SVS-1/SUSD2,vWDm, induces apopotosis in HeLa cells. Cancer Science. 98(6): 909-15. (2007)
[PMID: 17428257] |
8) |
Kurochkin IV, Mizuno Y, Konagaya A, Sakaki Y, Schonbach C, Okazaki Y. Novel peroxisomal protease Tysnd1 processes PTS1-and PTS2-containing enzymes involved in β-oxidation of fatty acids. The EMBO J. 26: 835-845. (2007)
[PMID: 17255948] |
9) |
Ninomiya Y, Yasuda T, Kawamoto M, Yuge O, Okazaki Y. Liver X receptor ligands inhibit the lipopolysaccharide-induced expression of microsomal prostaglandin E ynthase-1 and diminish prostaglandin E2 production in murine peritoneal macrophages. J. Steroid Biochem & Mol. Biol. 103: 44-50. (2007)
[PMID: 17049841] |
10) |
Shimokuni T, Tanimoto K, Hiyama K, Otani K, Ohtaki M, Hihara J, Yoshida K, Noguchi T, Kawahara K, Natsugoe S, Aikou T, Okazaki Y, Hayashizaki Y, Sato Y, Todo S, Hiyama E, Nishiyama M. Chemosensitivity prediction in esophageal squamous cell carcinoma: novel marker genes and efficacy-prediction formulae using their expression date. Int J Oncol. 28: 1153-62. (2006)
[PMID: 16596231] |
11) |
Horie-Inoue K, Takayama K, Bono H, Ouchi Y, Okazaki Y, Inoue S. Identification of novel steroid target genes through the combination of bioinformatics and functional analysis of hormone response elements. Biochem. Biophys. Res. Commun. 339: 99-106. (2006)
[PMID: 16289377] |
12) |
Hiyama K, Otani K, Ohtaki M, Satoh K, Kumazaki T, Takahashi T, Mitsui Y, Okazaki Y, Hayashizaki Y, Omatsu H, Noguchi T, Tanimoto K, Nishiyama M. Differentially expressed genes throughout the cellular immortalization processes are quite different between normal human fibroblasts and endothelial cells. Int J Oncol. 27: 87-95. (2005)
[PMID: 15942647] |
13) |
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schonbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y; FANTOM Consortium; RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group),The transcriptional landscape of the mammalian genome. Science. 309: 1559-63. (2005)
[PMID: 16141072] |
14) |
Matsuo K, Togo S, Sekido H, Morita T, Kamiyama M, Morioka D, Kubota T, Miura Y, Tanaka K, Ishikawa T, Ichikawa Y, Endo I, Goto H, Nitanda H, Okazaki Y, Hayashizaki Y, Shimada H. Pharmacologic preconditioning effects: prostaglandin E1 induces heat-shock proteins immediately after ischemia/reperfusion of the mouse liver. J Gastrointest Surg. 9(6) : 758-68. (2005)
[PMID: 15985230] |
15) |
Horie-Inoue K, Bono H, Okazaki Y, and Inoue S.Identification and functional analysis of consensus androgen response elements in human prostate cancer cell. Biochem. Biophys. Res. Commun. 325(4): 1312-7. (2004)
[PMID: 15555570] |
16) |
Fukuda K, Sakakura C, Miyagawa K, Kuriu Y, Kin S, Nakase Y, Hagiwara A, Mitsufuji S, Okazaki Y, Hayashizaki Y, Yamagishi H. Differential gene expression profiles of radioresistant oesophageal cancer cell lines established by continuous fractionated irradiation. Br J Cancer. 18; 91: 1543-50. (2004) |
17) |
Lin DM, Yang YH, Scolnick JA, Brunet LJ, Marsh H, Peng V, Okazaki Y, Hayashizaki Y, Speed TP, Ngai J. Spatial patterns of gene expression in the olfactory bulb. Proc. Natl. Acad. Sci. USA. 101: 12718-23. (2004)
[PMID: 15304640] |
18) |
Shimomura K, Sakakura C, Takemura M, Takagi T, Fukuda K, Kin S, Nakase Y, Miyagawa K, Ohgaki M, Fujiyama J, Fujita Y, Nakanishi M, Hagiwara A, Shirane M, Okazaki Y, Hayashizaki Y, Yamagishi H. Combination of L-3-phosphoserine phosphatase and CEA using real-time RT-PCR improves accuracy in detection of peritoneal micrometastasis of gastric cancer. Anticancer Res. 24: 1113-20. (2004)
[PMID: 15154633] |
19) |
Imanishi T, Itoh T, Suzuki Y, O'Donovan C, Fukuchi S, Koyanagi KO, Barrero RA, Tamura T, Yamaguchi-Kabata Y, Tanino M, Yura K, Miyazaki S, Ikeo K, Homma K, Kasprzyk A, Nishikawa T, Hirakawa M, Thierry-Mieg J, Thierry-Mieg D, Ashurst J, Jia L, Nakao M, Thomas MA, Mulder N, Karavidopoulou Y, Jin L, Kim S, Yasuda T, Lenhard B, Eveno E, Suzuki Y, Yamasaki C, Takeda J, Gough C, Hilton P, Fujii Y, Sakai H, Tanaka S, Amid C, Bellgard M, Bonaldo Mde F, Bono H, Bromberg SK, Brookes AJ, Bruford E, Carninci P, Chelala C, Couillault C, de Souza SJ, Debily MA, Devignes MD, Dubchak I, Endo T, Estreicher A, Eyras E, Fukami-Kobayashi K, Gopinath GR, Graudens E, Hahn Y, Han M, Han ZG, Hanada K, Hanaoka H, Harada E, Hashimoto K, Hinz U, Hirai M, Hishiki T, Hopkinson I, Imbeaud S, Inoko H, Kanapin A, Kaneko Y, Kasukawa T, Kelso J, Kersey P, Kikuno R, Kimura K, Korn B, Kuryshev V, Makalowska I, Makino T, Mano S, Mariage-Samson R, Mashima J, Matsuda H, Mewes HW, Minoshima S, Nagai K, Nagasaki H, Nagata N, Nigam R, Ogasawara O, Ohara O, Ohtsubo M, Okada N, Okido T, Oota S, Ota M, Ota T, Otsuki T, Piatier-Tonneau D, Poustka A, Ren SX, Saitou N, Sakai K, Sakamoto S, Sakate R, Schupp I, Servant F, Sherry S, Shiba R, Shimizu N, Shimoyama M, Simpson AJ, Soares B, Steward C, Suwa M, Suzuki M, Takahashi A, Tamiya G, Tanaka H, Taylor T, Terwilliger JD, Unneberg P, Veeramachaneni V, Watanabe S, Wilming L, Yasuda N, Yoo HS, Stodolsky M, Makalowski W, Go M, Nakai K, Takagi T, Kanehisa M, Sakaki Y, Quackenbush J, Okazaki Y, Hayashizaki Y, Hide W, Chakraborty R, Nishikawa K, Sugawara H, Tateno Y, Chen Z, Oishi M, Tonellato P, Apweiler R, Okubo K, Wagner L, Wiemann S, Strausberg RL, Isogai T, Auffray C, Nomura N, Gojobori T, Sugano S. Integrative Annotation of 21,037 Human Genes Validated by Full-Length cDNA Clones. PLoS Biol. 2: 856-75. (2004) |
20) |
Yagi K, Kondo D, Okazaki Y, Kano K.A novel preadipocyte cell line established from mouse adult mature adipocytes. Biochem. Biophys. Res. Commun. 321: 967-74. (2004)
[PMID: 15358122] |
21) |
Nagano Y, Nagahori K, Yoshiro F, Hamaguchi Y, Ishikawa T, Ichikawa Y, Togo S, Okazaki Y, Hayashizaki Y, and Shimada H. Gene expression profile analysis of regenerating liver after portal vein ligation in rats by a cDNA microarray system. Liver international. 24:253-8. (2004)
[PMID: 15189277] |
22) |
Sasazuki T, Okazaki T, Tada K, Sakon-Komazawa S, Katano M, Tanaka M, Yagita H, Okumura K, Tominaga N, Hayashizaki Y, Okazaki Y, Nakano H.Genome wide analysis of TNF-inducible genes reveals that antioxidant enzymes are induced by TNF and responsible for elimination of ROS. Molecular Immunology. 41: 547-51. (2004)
[PMID: 15183933] |
23) |
Kasukawa T , Bono H , Hayashizaki Y , Okazaki Y , and Matsuda H . MaXML: Mouse Annotation XML. In Silico Biology. 4: 7-15. (2004)
[PMID: 15089750] |
24) |
Togo S, Makino H, Kobayashi T, Morita T, Shimizu T, Kubota T, Ichikawa Y, Ishikawa T, Okazaki Y, Hayashizaki Y, Shimada H. Mechanism of liver regeneration after partial hepatectomy using mouse cDNA microarray. Journal of Hepatology. 40: 464-71. (2004)
[PMID: 15123361] |
25) |
Asano Y, Takashima S, Asakura M, Shintani Y, Liao Y, Minamino T, Asanuma H, Sanada S, Kim J, Ogai A, Fukushima T, Oikawa Y, Okazaki Y, Kaneda Y, Sato M, Miyazaki J, Kitamura S, Tomoike H, Kitakaze M, Hori M. Lamr1 functional retroposon causes right Ventricular dysplasia in mice. Nat. Genet. 36:123-30. (2004)
[PMID: 14730304] |
26) |
Gustincich S, Contini M, Gariboldi M, Puopolo M, Kadota K, Bono H, LeMieux J, Walsh P, Carninci P, Hayashizaki Y, Okazaki Y, Raviola E. Gene discovery in genetically labeled single retinal dopaminergic neurons. Proc. Natl. Acad. Sci. USA. 14: 5069・4. (2004)
r
[PMID: 15047890] |
27) |
Shimoji T, Kanda H, Kitagawa T, Kadota K, Asai R, Takahashi K, Kawaguchi N, Matsumoto S, Hayashizaki Y, Okazaki Y, Shinomiya K. Clinico-molecular study of dedifferentiation in well-differentiated liposarcoma, Biochem. Biophys. Res. Commun. 314:1133-40. (2004)
[PMID: 14751251] |
28) |
Sakakura C, Takemura M, Hagiwara A, Shimomura k, Miyagawa K, Nakashima S, Yoshikawa T, Takagi T, Kin S, Nakase Y, Fujiyama J, Hayasizaki Y, Okazaki Y, Yamagishi H. Overexpression of dopa decarboxylase in peritoneal dissemination of gastric cancer and its potential as a novel marker for the detection of peritoneal micrometastases with real-time RT-PCR. Br. J. Cancer. 90 : 665-71. (2004)
[PMID: 14760382] |
29) |
Tanaka T, Tanimoto K, Otani K, Satoh K, Ohtaki M, Yoshida K, Toge T, Yahata H, Tanaka S, Chayama K, Okazaki Y, Hayashizaki Y, Hiyama K, Nishiyama M. Concise prediction models of anticancer efficacy of 8 drugs using expression data from 12 selected genes. Int. J. Cancer. 10; 111: 617-26. (2004) |
30) |
Shimizu D, Ishikawa T, Ichikawa Y, Togo S, Hayasizaki Y, Okazaki Y, Shimada H. Current Progress in the Prediction of Chemosensitivity for Breast Cancer. Breast Cancer. 11: 42-8. (2004)
[PMID: 14718792] |
31) |
Nikaido I, Saito C, Wakamoto A, Tomaru Y, Arakawa T, Hayashizaki Y, Okazaki Y. EICO (Expression-based Imprint Candidate Organizer): finding disease-related imprinted genes. Nucleic Acids Research. 32: D548-D551. (2004)
[PMID: 14681478] |
32) |
Hou J, Yashiro K, Okazaki Y, Saijoh Y, Hayashizaki Y, and Hamada H. Identification of Novel Left-Right Asymmetrically Expressed Gene in the Mouse Belonging to The BPI/PLUNC Superfamily. Developmental Dynamics. 229: 373-9. (2004)
[PMID: 14745963] |
33) |
Wells CA, Ravasi T, Faulkner GJ, Carninci P, Okazaki Y, Hayashizaki Y, Sweet M, Wainwright BJ, Hume DA. Genetic control of the innate immune response. BMC Immunology. 4 : 5. (2003)
[PMID: 12826024] |
34) |
Futaki S, Hayashi Y, Yamashita M, Yagi K, Bono H, Hayashizaki Y, Okazaki Y, Sekiguchi K. Molecular Basis of Constitutive Production of BasementMembrane Components. J. Biol. Chem. 278: 50691-701. (2003)
[PMID: 12968032] |
35) |
Walsh NC, Cahill M, Carninci P, Kawai J, Okazaki Y, Hayashizaki Y, Hume DA, Cassady AI. Multiple tissue-specific promoters control expression of the murine tartrate-resistant acid phosphatase gene. Gene. 307: 111-23. (2003)
[PMID: 12706893] |
36) |
Sakakura C, Hagiwara A, Fukuda K, Shimomura K, Takagi T, Kin S, Nakase Y, Fujiyama J, Mikoshiba K, Okazaki Y, Yamagishi H. Possible involvement of inositol 1,4,5-trisphosphate receptor type 3(IP3R3)in the peritoneal dissemination of gastric cancers. Anticancer Res. 23: 3691-7. (2003)
[PMID: 14666665] |
37) |
Diaz E, Yang y. H, Ferreira T, Loh K.C, Okazaki Y, Hayashizaki Y, Lavigne M. T, Speed T.P, and Ngai J. Analysis of gene expression in the developing mouse retina. Proc. Natl. Acad. Sci. USA. 100 : 5491-6. (2003)
[PMID: 12702772] |
38) |
Garibaldi M, Spinola M, Milani S, Pignatiello C. Kadota K, Bono h, Hayashizaki Y, Dragani T.A, Okazaki Y. Gene expression profile of normal lungs predicts genetic predisposition to lung cancer in mice. Carcinogenesis. 24: 1819-26. (2003)
[PMID: 12919955] |
39) |
Kadota K, Nishimura S, Bono H, Nakamura S, Hayashizaki Y, Okazaki Y, and Takahashi K. Detection of genes with tissue-specific expression patterns using Akaike,s information criterion procedure. Physiol Genomics. 12: 251-9. (2003)
[PMID: 12499447] |
40) |
Carninci P, Waki K, Shiraki T, Konno H, Shibata K, Itoh M, Aizawa K, Arakawa T, Ishii Y, Sasaki D, Bono H, Kondo S, Sugahara Y, Saito R, Osato N, Fukuda S, Sato K, Watahiki A, Hirozane-Kishikawa T, Nakamura M, Shibata Y, Yasunishi A, Kikuchi N, Yoshiki A, Kusakabe M, Gustincich S, Beisel K, Pavan W, Aidinis V, Nakagawara A, Held WA, Iwata H, Kono T, Nakauchi H, Lyons P, Wells C, Hume DA, Fagiolini M, Hensch TK, Brinkmeier M, Camper S, Hirota J, Mombaerts P, Muramatsu M, Okazaki Y, Kawai J, Hayashizaki Y. Targeting a complex transcriptome: the construction of the mouse full-length cDNA Encyclopedia. Genome Res. 3: 1273-89. (2003)
[PMID: 12819125] |
41) |
Nikaido I, Saito C, Mizuno Y, Meguro M, Bono H, Kadomura M, Kondo S, Kono T, Morris G.A, Lyon P.A, Oshimura M, RIKEN GER Group Members, Hayashizaki Y. and Okazaki Y. Discovery of Imprinted Transcripts in the Mouse Transcriptome Using Large Scale Expression Profiling. Genome Res. 13: 1402-9. (2003)
[PMID: 12819139] |
42) |
Kasukawa T, Furuno M, Nikaido I, Bono H, Hume D.A, Bult C, Hill D.P, Baldarelli R, Gough J, Kanapin A, Matsuda H, Schriml L, Hayashizaki Y, Okazaki Y, and Quackenbush J. Development and Evaluation of an Automated Annotation Pipeline and cDNA Annotation System, Genome Res. 13 : 1542-51. (2003)
[PMID: 12819153] |
43) |
Bono H, Yagi K, Kasukawa T, Nikaido I, Tominaga N, Miki R, Mizuno Y, Tomaru Y, Goto H, Nitanda H, Shimizu D, Makino H, Morita T, Fujiyama J, Sakai T, Shimoji T, Hume D.A, RIKEN GER Group and GSL Members, Hayashizaki, Y, and Okazaki Y. Systematic expression profiling of the mouse transcriptome using RIKEN cDNA microarrays. Genome Res. 13: 1318-23. (2003)
[PMID: 12819129] |
44) |
Bono H, Nikaido I, Kasukawa T, Hayashizaki Y, RIKEN GER Group Members (arakawa T, Carninci P, Kawai J.) and Okazaki Y, Comprehensive Analysis of the Mouse Metabolome base upon the Transcriptome, Genome Res. 13: 1345-49. (2003) |
45) |
Schriml L.M, Hill D.P, Blake J.A, Bono H, Wynshaw-boris A, Pavan W.J, Ring B.A, Beisel K, Setou M, RIKEN GER Group Members(Arakawa T, Carninci P, Kawai J), Okazaki Y, and Hayashizaki Y. Human Disease Genes and their cloned Mouse Orthologs: Exploration of the FANTOM2 cDNA Sequence Dataset, Genome Res. 13 : 1496-500. (2003)
[PMID: 12819148] |
46) |
Wells C, Ravasi T, Sultana R, Yagi K, Carninci P, Bono H, Faulkner G, Okazaki Y, Quackenbush J, Hume D.A. and RIKEN GER Group, Contunued discovery of transcriptional units expressed in cells of the mouse mononuclear phagocyte lineage, Genome Res. 13 : 1360-65. (2003) |
47) |
Gustincich S, Batalov S, Beisel KW, Bono H, Carninci P, Fletcher CF, Grimmond S, Hirokawa N, Jarvis ED, Jegla T, Kawasawa Y, Lemieux J, Miki H,Raviola E, Teasdale RD, Tominaga N, Yagi K, Zimmer A, Hayashizaki Y, Okazaki Y. Analysis of Mouse Transcriptome for Genas Involved in the Function of the Nervous System. Genome Res. 13: 1395-401. (2003)
[PMID: 12819138] |
48) |
Furuno M, Kasukawa T, Saito R, Adachi J, Suzuki H, Baldarelli R, Hayashizaki Y, Okazaki Y. CDS Annotation in Full-Length cDNA Sequence. Genome Res. 13 : 1478-87. (2003)
[PMID: 12819146] |
49) |
Gariboldi M, Peissel B, Fabbri A, Saran A, Zaffaroni D, Falvella F.S, Spinola A, Pazzaglia S, Tanuma T, Maurichi T, Bartoli C, Silverman G, Mancuso M.T, Pilotti S, Hayashizaki Y, Okazaki Y, and Dragani T.A, SCCA2-like Serpins Mediate Genetic Predisposition to Skin Tumors, Cancer Res. 63 : 1871-75. (2003) |
50) |
Grimmond SM, Miranda KC, Yuan Z, Davis MJ, Hume DA, Yagi K, Tominaga N, Bono H, Hayashizaki Y, Okazaki Y, Teasdale RD; RIKEN GER Group; GSL Members. The mouse secretome: functional classification of the proteins secreted into the extracellular environment. Genome Res. 13: 1350-9. (2003)
[PMID: 12819133] |
51) |
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schonbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y; The FANTOM Consortium.; RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs, Nature. 420: 563-73. (2002) |
52) |
Waterston RH, Lindblad-Toh K, Birney E, Rogers J, Abril JF, Agarwal P, Agarwala R, Ainscough R, Alexandersson M, An P, Antonarakis SE, Attwood J, Baertsch R, Bailey J, Barlow K, Beck S, Berry E, Birren B, Bloom T, Bork P, Botcherby M, Bray N, Brent MR, Brown DG, Brown SD, Bult C, Burton J, Butler J, Campbell RD, Carninci P, Cawley S, Chiaromonte F, Chinwalla AT, Church DM, Clamp M, Clee C, Collins FS, Cook LL, Copley RR, Coulson A, Couronne O, Cuff J, Curwen V, Cutts T, Daly M, David R, Davies J, Delehaunty KD, Deri J, Dermitzakis ET, Dewey C, Dickens NJ, Diekhans M, Dodge S, Dubchak I, Dunn DM, Eddy SR, Elnitski L, Emes RD, Eswara P, Eyras E, Felsenfeld A, Fewell GA, Flicek P, Foley K, Frankel WN, Fulton LA, Fulton RS, Furey TS, Gage D, Gibbs RA, Glusman G, Gnerre S, Goldman N, Goodstadt L, Grafham D, Graves TA, Green ED, Gregory S, Guigo R, Guyer M, Hardison RC, Haussler D, Hayashizaki Y, Hillier LW, Hinrichs A, Hlavina W, Holzer T, Hsu F, Hua A, Hubbard T, Hunt A, Jackson I, Jaffe DB, Johnson LS, Jones M, Jones TA, Joy A, Kamal M, Karlsson EK, Karolchik D, Kasprzyk A, Kawai J, Keibler E, Kells C, Kent WJ, Kirby A, Kolbe DL, Korf I, Kucherlapati RS, Kulbokas EJ, Kulp D, Landers T, Leger JP, Leonard S, Letunic I, Levine R, Li J, Li M, Lloyd C, Lucas S, Ma B, Maglott DR, Mardis ER, Matthews L, Mauceli E, Mayer JH, McCarthy M, McCombie WR, McLaren S, McLay K, McPherson JD, Meldrim J, Meredith B, Mesirov JP, Miller W, Miner TL, Mongin E, Montgomery KT, Morgan M, Mott R, Mullikin JC, Muzny DM, Nash WE, Nelson JO, Nhan MN, Nicol R, Ning Z, Nusbaum C, O'Connor MJ, Okazaki Y, Oliver K, Overton-Larty E, Pachter L, Parra G, Pepin KH, Peterson J, Pevzner P, Plumb R, Pohl CS, Poliakov A, Ponce TC, Ponting CP, Potter S, Quail M, Reymond A, Roe BA, Roskin KM, Rubin EM, Rust AG, Santos R, Sapojnikov V, Schultz B, Schultz J, Schwartz MS, Schwartz S, Scott C, Seaman S, Searle S, Sharpe T, Sheridan A, Shownkeen R, Sims S, Singer JB, Slater G, Smit A, Smith DR, Spencer B, Stabenau A, Stange-Thomann N, Sugnet C, Suyama M, Tesler G, Thompson J, Torrents D, Trevaskis E, Tromp J, Ucla C, Ureta-Vidal A, Vinson JP, Von Niederhausern AC, Wade CM, Wall M, Weber RJ, Weiss RB, Wendl MC, West AP, Wetterstrand K, Wheeler R, Whelan S, Wierzbowski J, Willey D, Williams S, Wilson RK, Winter E, Worley KC, Wyman D, Yang S, Yang SP, Zdobnov EM, Zody MC, Lander ES; Mouse Genome Sequencing Consortium., Initial sequencing and comparative analysis of the mouse genome, Nature. 420: 520-62. (2002) |
| REVIEW |
53) |
Bono H, Okazaki Y, Study of Mouse Metabolic Pathways Using cDNA Microarrays, "Prespectives in Gene Expression", PerkinElmer Life Sciences, 103-131 (2003) |
|
|