SECTION

Division of Gene Structure and Function Division of Gene Regulation and Signal Transduction
Division of Developmental Biology Division of Pathophysiogy
Division of Functional Genomics & Systems Medicine Division of Gene Therapy and Genome Editing
Division of Translational Research  
Division of Functional Genomics & Systems Medicine
概要 Research Summary
 

Although human genome sequence has completed in April 2003, the whole gene annotation and functional annotation of each gene is yet to be done. In our laboratory we are focusing more on the functional genomics based on the genome-wide approach combined with genetic approach. We are also targeting on a research of gene network and pathological network of diseased conditions by analyzing the genome-wide data derived from many model organisms using bioinformatics. By using a comparative genomics approach, we will try to understand the pathophysiological condition and to find a cure for common diseases. We are hoping to bridge the gap between basic science and clinical medicine.

Figure 1.

Figure 1.

 

Figure 2.

Figure 2.

 
スタッフ Staff
Professor Akihiko Okuda
Assistant Professor Masahito Matsumoto, Yosuke Mizuno
Assistant Yukiko Yatsuka
Senior Research Fellow Sze Chern Lim
Graduate Student Nurun Nahar Borna, Megumi Yumoto, Taketo Tomoda, Naoki Hayashi, Eiji Ikami
Project Technical Assistant Chiharu Shimizu, Michiko Ishida, Momoe Ohkubo
Visiting Professor Tatsuo Suda, Yasushi Okazaki
Visiting Associate Professor Hideo Toyoshima
Visiting Assistant Professor Atsuko Imai
Researcher Tsuyoshi Sato
テーマ Research Projects
1)
Identification of causative genes for mitochondrial respiratory chain disorder (MRCD) (Figure 1)
2)
Identification and description of gene regulatory networks in common diseases such as metabolic syndrome, diabetes mellitus, and ischemic disease (Figure 2)
3)
Genome research for regeneration of pancreatic islets and beta cells aimed at regenerative medicine for diabetes and glycometabolic disorders
4)
Search for novel target genes that improve common lifestyle diseases
5)
Translational research for identification of disease genes (discovery of diagnostic markers, order-made medicine, search for novel biologically active substances)
文献 References
Borna N.N, et al. Novel mutation in TAZ causes mitochondrial respiratory chain disorder without cardiomyopathy. Journal of Human Genetics in press, (2016)
[PMID:28123175]
Yamashita-Sugahara Y, et al. An inhibitor of fibroblast growth factor receptor-1 (FGFR1) promotes late-stage terminal differentiation from NGN3+ pancreatic progenitors. Scientific Reports 6: 35908, (2016)
[PMID:27786288]
Okazaki Y, et al. IARS Mutations Cause Growth Retardation with Prenatal Onset, Intellectual Disability, Muscular Hypotonia, and Infantile Hepatopathy. Am J Hum Genet 99:414-22, (2016)
[PMID:27426735]
Imai A, et al. Dried blood spots for newborn screening allows easy determination of a high heteroplasmy rate in severe infantile cardiomyopathy. International Journal of Cardiology 221:446-449, (2016)
[PMID:27409572]
Kohda M, Tokuzawa Y, Kishita Y, et al. A comprehensive genomic analysis reveals the genetic landscape of mitochondrial respiratory chain complex deficiencies. PLOS Genet 12(1) e1005679, (2016)
[PMID:26741492]
Iseki H, et al. Combined Overexpression of JARID2, PRDM14, ESRRB, and SALL4A Dramatically Improves Efficiency and Kinetics of Reprogramming to Induced Pluripotent Stem Cells. Stem Cells. 34(2):322-33, (2016)
[PMID:26523946]
Kishita Y, et al. Intra-mitochondrial methylation deficiency due to mutations in SLC25A26. Am J Hum Genet 97(5):761-8, (2015)
[PMID:26522469]
Nakachi Y, et al. Gene expression profile of the neonatal female mouse brain after administration of testosterone propionate. J Sex Med. 12:887-96, (2015)
[PMID:25630233]
Okazaki Y, et al. COQ4 mutations cause a broad spectrum of mitochondrial disorders associated with CoQ10 deficiency. Am J Hum Genet 5;96:309-17, (2015)
[PMID:25658047]
FANTOM Consortium and the RIKEN PMI and CLST (DGT). Gene regulation. Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells. Science. 347: 1010-1014, (2015)
[PMID:25678556]
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