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埼玉医科大学雑誌 第30巻 第2号 (2003年4月) 131-137頁 ◇論文(図表を含む全文)は，PDFファイルとなっています． PDF (1.2 MB) 原 著 新しい方法を用いた，モルモットの咳に対する中枢性鎮咳薬の効果の検討 河本 定則1），田中 求2），坂本 芳雄1） 1）埼玉医科大学第二内科学教室呼吸器科 2）埼玉医科大学薬理学教室 〔平成15年2月6日 受付〕 Evaluation of Effects of Central Antitussives on Cough Motion by New Method in Guinea Pig 1)Sadanori Kawamoto, 2)Motomu Tanaka, 1)Yoshio Sakamoto (Pulmonary Division, Second Department of Internal Medicine1), Department of Pharmacology2), Saitama Medical School, Moroyama, Iruma-gun, Saitama 350-0495, Japan) The present study was conducted to evaluate the effects of dextromethorphan and codeine on the elements of the coughing motion under the condition of upper respiratory inflammation. Coughs were induced by microinjection of citric acid into the upper trachea of conscious and unrestrained guinea pig. Cough numbers were counted and cough expiratory peak flows, expiration time and inspiratory peak flows were measured by a one-chambered whole body plethysmograph. The percent inhibitions of the values by intraperitoneal administration of the antitussives were assessed. Cough numbers were reduced by both drugs. But cough expiratory peak flows were reduced more effectively by administration of dextromethorphan. Cough expiration time and inspiratory peak flow were not affected significantly by either dextromethorphan or codeine. These results suggest that there are differences between dextromethorphan and codeine in terms of effects to cough pattern generator. It would be important to assess the percent inhibition of cough expiratory peak flow as well as those of cough numbers when evaluating the efficiency of an antitussive. Keywords: Dextromethorphan, Codeine, Citric acid, Microinjection, Cough J Saitama Med School 2003; 30: 131-137 (Received February 6, 2003)
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