埼玉医科大学雑誌 第41巻 第2号 (2015年3月) 127-133頁 ◇論文(図表を含む全文)は，PDFファイルとなっています．

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原　著
造影剤による乳腺 proton MR spectroscopy の choline ピーク減少に関する基礎的研究

水越　和歌1)＊，小澤　栄人1)，桜井　靖雄2)，妹尾　大樹2)，井上　快児3)，木村　文子1)
1) 埼玉医科大学　国際医療センター　画像診断科
2) 埼玉医科大学　国際医療センター　中央放射線部
3) 埼玉医科大学　大学病院　放射線科

〔平成26年3月25日 受付 / 平成26年9月11日 受理〕

The effects of paramagnetic contrast media on choline peak in proton MR spectroscopy of the breast: a preliminary study
Waka Mizukoshi1)＊, Eito Kozawa1), Yasuo Sakurai2), Taiki Senoo2), Kaiji Inoue3), and Fumiko Kimura1)
1)Department of Diagnostic Radiology, Saitama International Medical Center, Saitama Medical University
2)Department of Radiology, Saitama International Medical Center, Saitama Medical University
3)Department of Radiology, Saitama Medical University Hospital, Saitama Medical University


　Administration of contrast media before proton magnetic resonance spectroscopy (1H MRS) may allow more accurate placement of the volume of interest in breast tumors, but some studies have suggested their use decreases the choline peak. We studied the impact of contrast use to determine which method would reduce the choline peak the least.
　Phantoms containing 1, 5, and 10 mM concentrations of choline were prepared in phosphate-buffered saline and mixed with contrast media in concentrations of 0, 0.2, 0.4, and 0.6 mM. We used 2 different media: one being a negatively-charged diethylenetriaminepentaacetic acid gadolinium (Gd-DTPA), and the other a neutral gadoteridol (Gd-HP-DO3A). We studied all phantoms by single voxel 1H MRS with a repetition time (TR) of 2,000 msec and an echo time (TE) of 136 or 270 msec.
　Gd-DTPA tended to induce an increase in the peak integral and amplitude at lower concentrations and a decrease at a higher concentration, whereas Gd-HP-DO3A tended to induce an increase in the peak integral and amplitude at lower concentrations with no definite decrease at higher concentrations. Neither contrast medium induced a definite change in peak width. The reduction of the choline peak integral and amplitude at TE of 270 msec was greater than at TE of 136 msec.
　Therefore, we recommend the use of the neutral contrast agent and short TE in 1H MRS studies of breast tumors to avoid underestimation of the level of choline peaks.

J Saitama Medical University 2015; 41(2): 127-133
(Received March 25, 2014 / Accepted September 11, 2014)

Keywords: MR spectroscopy, breast tumor, choline peak, contrast media
(C) 2015 The Medical Society of Saitama Medical University