Takagi Rie
　
Last updated: January 16, 2023

高木　理英

　　　　

　

経歴：

2001年3月 埼玉医科大学短期大学卒業
2001年4月 埼玉医科大学医学部免疫学・実験助手
2009年8月 埼玉医科大学医学部免疫学・助手
2014年3月 放送大学卒業

所属学会：

・日本免疫学会
・日本アレルギー学会

獲得研究費：

・令和3-5年度　文部科学省科学研究費　基盤研究(C)(21K09920) 「ド−パミンD2受容体活性による好中球性炎症抑制の解析」
・平成30-32年度　文部科学省科学研究費　若手研究(18K15327) 「隠蔽自己抗原を用いた新規がん免疫療法の開発」
・平成28年度　埼玉医科大学学内グラント　関口記念特別賞 「メラノーマの新規治療法に関する基礎的研究」
・平成27年度　埼玉医科大学研究マインド支援グラント 基礎医学系若手限定研究費 「メラノーマの新規治療法に関する基礎的研究」
・平成22-25年度　文部科学省科学研究費　若手研究B（22790940） 「アレルギー・自己免疫病におけるヒトTh17/Th21細胞の解析」

研究業績：

  1. 論文／著書
      2008年
    1. Higashi, T., Wakui, M., Nakano, K., Hashimoto, K.,Takagi, R., Tanaka, Y. and Matsushita, S. Evaluation of adjuvant activities using human antigen presenting cells in vitro.
      Allergol. Int.57:219-222, 2008.
    2. Takagi, R., Higashi, T., Hashimoto, K., Nakano, K., Mizuno, Y., Okazaki, Y. and Matsushita, S. B-cell chemoattractant CXCL13 is preferentially expressed by human Th17 cell clones.
      J. Immunol. 181:186-189, 2008.
    3. Nakano, K., Higashi, T., Hashimoto, K., Takagi, R., Tanaka, Y. and Matsushita, S. Antagonizing dopamine D1-like receptor inhibits Th17 cell differentiation: Preventive and therapeutic effects on experimental autoimmune encephalomyelitis.
      Biochem. Biophys. Res. Commun. 373:286-291, 2008.

      4. 2009年
    4. Nakano, K., Higashi, T., Takagi, R., Hashimoto, K., Tanaka, Y. and Matsushita, S. Dopamine released by dendritic cells polarizes Th2 differentiation.
      Int. Immunol.June 2009 ; 21:645-654.
    5. Hashimoto, K., Inoue, T., Higashi, T., Takei S., Katayama S., Takagi, R., Okada, H., Matsushita, S. Dopamine D1-like receptor antagonist, SCH23390, exhibits a preventive effect on diabetes mellitus that occurs naturally in NOD mice .
      Biochem. Biophys. Res. Commun. 383(4)460-463, 2009.

      6. 2010年
    6. Higashi T, Hashimoto K, Takagi R, Mizuno Y, Okazaki Y, Tanaka Y and Matsushita S. Curdlan induces DC-mediated Th17 polarization via Jagged1 activation in human dendritic cells.
      Allergol. Int. 59;161-166,2010.
    7. 松下　祥、高木理英：Th17細胞の産生ケモカインとその意義。
      臨床免疫・アレルギー科, 53(2); 229-234, 2010.

      8. 2011年
    8. Matsushita, S., Takagi, R., Hashimoto, K., Higashi, T. Qualitative evaluation of adjuvant activities and its application to Th2/17 diseases.
      Int. Arch. Allergy Immunol. 155(suppl. 1): 2-5, 2011
    9. Nakagome, K., Imamura, M., Okada, H., Kawahata, K., Inoue, T., Hashimoto, K., Harada, H., Higashi, T., Takagi, R., Nakano, K., Hagiwara, K., Kanazawa, M., Dohi, M., Nagata, M., Matsushita, S. Dopamine D1-like receptor antagonist attenuates Th17-mediated immune response and OVA-Ag-induced neutrophilic airway inflammation.
      J. Immunol., 186:5975-5982, 2011.
    10. Higashi, T., Shimojo, N., Suzuki, S., Nakaya, M., Takagi, R., Hashimoto, K., Nakagome, K., Nakamura, K., Kohno, Y. and Matsushita, S. Coenzyme A contained in mothers’ milk is associated with the potential to induce atopic dermatitis.
      Int. Immunol. 23:741-749, 2011

      11. 2014年
    11. Takagi, R., Kawano, M., Nakagome, K., Hashimoto, K., Higashi, T., Ohbuchi, K., Kaneko, A. and Matsushita, S. Wogonin attenuates ovalbumin antigen-induced neutrophilic airway inflammation by inhibiting Th17 differentiation.
      Int. J. Inflamm., Vol. 2014, Article ID 571508, 8 pages.
      http://dx.doi.org/10.1155/2014/571508
    12. Rie Takagi, Masaaki Kawano and Sho Matsushita. Dopamine modulates Th17-mediated autoimmunity via dopamine receptors expressed on dendritic cells and naive CD4 T cells.
      Current Trends in Immunology, 15: 9-17, 2014.

      13. 2015年
    13. Masaaki Kawano1, Rie Takagi, Atsushi Kaneko and Sho Matsushita. Berberine is a dopamine D1-, D2-like receptor antagonist and ameliorates experimentally induced colitis by suppressing innate and adaptive immune responses.
      J. Neuroimmunol., 289 : 43-55, 2015.

      14. 2016年
    14. Rie Takagi, Masaaki Kawano, Koichiro Nakamura, Tetsuya Tsuchida and Sho Matsushita.T-cell responses to tyrosinase-derived self-peptides in patients with leukoderma induced by rhododendrol: Implications for immunotherapy targeting melanoma.
      Dermatology, 232 : 44-49, 2016.

      15. 2017年
    15. 高木理英、松下祥：ロドデノール誘発性白班症は自己免疫病である。
      臨床皮膚科71巻5号42-45.
    16. Yutaka Enomoto, Rie Takagi, Yutaka Naito, Tsuyoshi Kiniwa, Yasuhito Tanaka, Susumu Hamada-Tsutsumi, Masaaki Kawano, Sho Matsushita, Takahiro Ochiya, and Atsushi Miyajima. Identification of the novel 3’ UTR sequences of human IL-21 mRNA as potential targets of miRNAs.
      Scientific Reports, 7:7780, 2017 DOI:10.1038/s41598-017-07853-x
    17. Itano, A., Kawano , M., Takagi, R., Tokuyama, K. and Matsushita, S. Signaling via FceRI stimulates human immature dendritic cells to induce Th1 differentiation via IL-12: Novel evidence of a feedback loop of allergic responses mediated by dendritic cells.
      Current Trends in Immunology.18:57_65, 2017.

      18. 2018年
    18. Matsueda, H., Kawano, M., Takagi, R., Koshimizu, K. and Matsushita, S. Acetylcholine stored in dendritic cells plays a role in the differentiation of naive CD4+ T cells into a Th1 phenotype.
      Clin Exp. Neuroimmunol. 9: 115-123, 2018.
    19. Matsuyama, T., Kawano, M., Takagi, R., Nakagome, K., Chikamatsu, K., Matsushita, S. IL-8 produced by T cells is under the control of dopamine signaling.
      Clin. Exp. Neuroimmunol. 9:251-257, 2018.
    20. Kenji Nishizawa, Rie Takagi, Masaaki Kawano, and Sho Matsushita. Protein kinase C activation via serotonin receptor induces IL-8 in antigen-presenting cells stimulated with diazinon.
      Current Topics in Toxicology 14:41-52, 2018.
    21. 土田哲也、中村晃一郎、高木理英、川野雅章、松下　祥：ロドデノール誘発性脱色素班は自己免疫機序により生じる、宮地良樹編：「What’s new in 皮膚科学」
      メディカルレビュー社（東京）pp44-45, 2018
    22. Kawano, M., Takagi, R.,Saika, K., Matsui, M and Matsushita, S. Dopamine regulates cytokine secretion during innate and adaptive immune responses.
      Int. Immunol. 30(12) 591-606, 2018. DOI:10.1093/intimm/dxy057

      23. 2020年
    23. Kawano, M., Saika, K., Takagi, R., Matsui, M. and Matsushita, S. Tannic acid acts as an agonist of the dopamine D2L receptor, regulates immune responses, and ameliorates experimentally induced colitis in mice.
      Brain, Behavior, & Immunity-Health 5: 100071, 2020.

      24. 2021年
    24. Rie Takagi, Masaaki Kawano, Tsuyoshi Sato and Sho Matsushita. Tannic acid, a dopamine receptor agonist, ameliorates periodontitis, atopic dermatitis and psoriasis in animal models.
      Current Trends in Immunology 22: 11-17, 2021.
    25. Tokano, M., Kawano, M., Takagi, R. and Matsushita, S. Istradefylline, an adenosine A2a receptor antagonist, ameliorates neutrophilic airway inflammation and psoriasis in mice.
      Clin. Exp. Neuroimmunol. 12: 268-275, 2021.

      26. 2022年
    26. Mieko Tokano, Rie Takagi, Masaaki Kawano, Shigefumi Maesaki, Norihito Tarumoto and Sho Matsushita. Signaling via dopamine and adenosine receptors modulate viral peptide-specific and T-cell IL-8 response in COVID-19.
      Immunol. Med. 45:162-167, 2022
    27. Mieko Tokano, Masaaki Kawano, Rie Takagi, and Sho Matsushita. Istradefylline, an adenosine A2a receptor antagonist, inhibits the CD4+T-cell hypersecretion of IL-17A and IL-8 in humans.
      Immunol. Med. Immunol. Med. 45: 244-250, 2022
    28. Yuta Isozaki, Tsuyoshi Sato, Rie Takagi, Ko Ito, Michihiko Usui, Masaaki Kawano, Sho Matsushita. Ropinirole inhibits inflammatory cytokine production in gingival epithelial cells and suppresses alveolar bone loss in an experimental rat model of periodontitis.
      Experimental and Therapeutic Medicine., in press.
    29. Mieko Tokano, Sho Matsushita, Rie Takagi, Toshimasa Yamamoto, and Masaaki Kawano. Extracellular adenosine induces hypersecretion of IL-17A by T-helper 17 cells through the adenosine A2a receptor.
      Brain, Behavior, & Immunity - Health, in press.
      30. 2023年
    30. Masaaki Kawano, Rie Takagi, Mieko Tokano, and Sho Matsushita. Adenosine induces IL-31 secretion by T-helper 2 cells: Implication for the effect of adenosine on atopic dermatitis and its therapeutic strategy. Biochem. Biophys. Res. Commun. 645 : 47-54, 2023.