Carrer

-January 2022~present
Assistant Professor, Department of Pharmacology, Faculty of Medicine, Saitama Medical University
- January 2017~December 2021
Instructor, Department of Pharmacology, Faculty of Medicine, Saitama Medical University
-April 2014~December 2016
Research Fellow, Department of Neurochemistry, Graduate School of Medicine, The University of Tokyo
-March 2014
Ph.D. Department of Neurochemistry, Graduate School of Medicine, The University of Tokyo

 

Key Word

Alzheimer’s disease, tau, synapse, O.degus, Autism Spectrum Disorder
Activity dependent gene expression, Immediate Early Genes, Arc, In vivo imaging

 

Publication

1. Yagishita-Kyo N*, Ikai Y, Uekita T, Shinohara A, Koshimoto C, Yoshikawa K, Maruyama K, Yagishita S. Testosterone interrupts binding of Neurexin and Neuroligin that are expressed in a highly socialized rodent, Octodon degus. Biochemical and Biophysical Research Communications. 2021, 551, pp54-62, DOI: 10.1016/j.bbrc.2021.03.015

2. Okuno H, Akashi K, Ishii Y, Yagishita-Kyo N, Suzuki K, Nonaka M, Kawashima T, Fujii H, Takemoto-Kimura S, Abe M, Natsume R, Chowdhury S, Sakimura K, P F. Worley and Bito H, Inverse synaptic tagging of inactive synapses via dynamic interaction of Arc/Arg3.1 with CaMKIIβ. Cell. 149(4), 886-898, (2012)

3. Yagishita-Kyo N, Inoue M, Nonaka M, Okuno H, and Bito H. contribution: CREB. Encyclopedia of Signaling Molecules. 454-458. (2012)

4. Inoue M, Yagisihita-Kyo N, Nonaka M, Kawashima T, Okuno H, and Bito H. Synaptic Activity Responsive Element (SARE): a unique genomic structure with an unusual sensitivity to neuronal activity. Commun Integr Biol. 3(5):443-446. (2010)

5. Kawashima T, Okuno H, Nonaka M, Adachi-Morishima A, Kyo N, Okamura M, Takemoto-Kimura S,　Worley F. P, and Bito H. Synaptic activity-responsive element in the Arc/Arg3.1 promoter essential for synapse-to-nucleus signaling in activated neurons. Proc Natl Acad Sci USA. 106(1), 316-321, (2009)