略歴
私立武蔵高等学校卒業
山梨医科大学医学部卒業
山梨医科大学大学院医学研究科生理系修了(医学博士)
国立小児病院小児医療研究センター・小児薬理部・重点領域研究協力員（平成）
東京女子医科大学第二生理学教室講師
埼玉医科大学薬理学教室准教授
主な論文
1 Bando, T., Toda, H. & Awaji, T. Lens accommodation-related and pupil-related
units in the lateral suprasylvian area in cats. Prog Brain Res 75, 231-236
(1988).
2 Wu, Z., Awaji, T., Motomura, S. & Hashimoto, K. [Effects of a new
antiarrhythmic drug, KW-3407, on canine ventricular arrhythmia models].
Nihon Yakurigaku Zasshi 100, 117-126 (1992).
3 Awaji, T. & Hashimoto, K. Antiarrhythmic effects of combined application
of class I antiarrhythmic drugs; addition of low-dose mexiletine-enhanced
antiarrhythmic effects of disopyramide and aprindine in various-rate canine
ventricular tachycardias. J Cardiovasc Pharmacol 21, 960-966 (1993).
4 Hirasawa, A., Awaji, T., Hosono, M., Haruno, A. & Hashimoto, K. Effects
of a new forskolin derivative, NKH477, on canine ventricular arrhythmia
models. J Cardiovasc Pharmacol 22, 847-851 (1993).
5 Wu, Z., Awaji, T., Abe, H., Motomura, S. & Hashimoto, K. Effects
of OPC-18790, a new positive inotropic agent, on canine ventricular arrhythmias.
Jpn J Pharmacol 63, 399-404 (1993).
6 Zhenjiu, W., Awaji, T., Hirasawa, A., Motomura, S. & Hashimoto, K.
Effects of a new class I antiarrhythmic drug bidisomide on canine ventricular
arrhythmia models. Mol Cell Biochem 119, 159-169 (1993).
7 Awaji, T., Wu, Z. J. & Hashimoto, K. Acute antiarrhythmic effects
of intravenously administered amiodarone on canine ventricular arrhythmia.
J Cardiovasc Pharmacol 26, 869-878 (1995).
8 Hashimoto, K., Haruno, A., Hirasawa, A., Awaji, T., Xue, Y. & Wu,
Z. Effects of the new class III antiarrhythmic drug MS-551 and d-sotalol
on canine coronary ligation-reperfusion ventricular arrhythmias. Jpn J
Pharmacol 68, 1-9 (1995).
9 Awaji, T., Izumi, S., Horie, K., Hirasawa, A. & Tsujimoto, G. Alpha
1b-adrenoceptor-mediated calcium oscillation is specific for the S phase
in cell cycle and dependent on the extracellular calcium. Biochem Biophys
Res Commun 224, 80-86, doi:S0006291X96909870 [pii] (1996).
10 Hirasawa, A., Tsumaya, K., Awaji, T., Shibata, K., Homma, N., Shinomiya,
T. & Tsujimoto, G. Flow cytometry analysis of alpha1-adrenoceptor subtypes.
FEBS Lett 386, 141-148 (1996).
11 Saito, H., Ebisawa, M., Tachimoto, H., Shichijo, M., Fukagawa, K., Matsumoto,
K., Iikura, Y., Awaji, T., Tsujimoto, G., Yanagida, M., Uzumaki, H., Takahashi,
G., Tsuji, K. & Nakahata, T. Selective growth of human mast cells induced
by Steel factor, IL-6, and prostaglandin E2 from cord blood mononuclear
cells. J Immunol 157, 343-350 (1996).
12 Hirasawa, A., Sugawara, T., Awaji, T., Tsumaya, K., Ito, H. & Tsujimoto,
G. Subtype-specific differences in subcellular localization of alpha1-adrenoceptors:
chlorethylclonidine preferentially alkylates the accessible cell surface
alpha1-adrenoceptors irrespective of the subtype. Mol Pharmacol 52, 764-770
(1997).
13 Takada, T., Iida, K., Awaji, T., Itoh, K., Takahashi, R., Shibui, A.,
Yoshida, K., Sugano, S. & Tsujimoto, G. Selective production of transgenic
mice using green fluorescent protein as a marker. Nat Biotechnol 15, 458-461
(1997).
14 Awaji, T., Hirasawa, A., Kataoka, M., Shinoura, H., Nakayama, Y., Sugawara,
T., Izumi, S. & Tsujimoto, G. Real-time optical monitoring of ligand-mediated
internalization of alpha1b-adrenoceptor with green fluorescent protein.
Mol Endocrinol 12, 1099-1111 (1998).
15 Hirasawa, A., Awaji, T., Sugawara, T., Tsujimoto, A. & Tsujimoto,
G. Differential mechanism for the cell surface sorting and agonist-promoted
internalization of the alpha1B-adrenoceptor. Br J Pharmacol 124, 55-62
(1998).
16 Ono, S., Baux, G., Sekiguchi, M., Fossier, P., Morel, N. F., Nihonmatsu,
I., Hirata, K., Awaji, T., Takahashi, S. & Takahashi, M. Regulatory
roles of complexins in neurotransmitter release from mature presynaptic
nerve terminals. Eur J Neurosci 10, 2143-2152 (1998).
17 Take, H., Shibata, K., Awaji, T., Hirasawa, A., Ikegaki, I., Asano,
T., Takada, T. & Tsujimoto, G. Vascular alpha1-adrenoceptor subtype
selectivity and alpha1-blocker-induced orthostatic hypotension. Jpn J Pharmacol
77, 61-70 (1998).
18 Tsujimoto, G., Hirasawa, A., Sugawara, T. & Awaji, T. Subtype-specific
differences in subcellular localization and chlorethylclonidine inactivation
of alpha1-adrenoceptors. Life Sci 62, 1567-1571 (1998).
19 Koike, M., Awaji, T ., Kataoka, M., Tsujimoto, G., Kartasova, T., Koike,
A. & Shiomi, T. Differential subcellular localization of DNA-dependent
protein kinase components Ku and DNA-PKcs during mitosis. J Cell Sci 112
( Pt 22), 4031-4039 (1999).
20 Aida, T., Oda, S., Awaji, T., Yoshida, K. & Miyazaki, S. Expression
of a green fluorescent protein variant in mouse oocytes by injection of
RNA with an added long poly(A) tail. Mol Hum Reprod 7, 1039-1046 (2001).
21 Awaji, T., Hirasawa, A., Shirakawa, H., Tsujimoto, G. & Miyazaki,
S. Novel green fluorescent protein-based ratiometric indicators for monitoring
pH in defined intracellular microdomains. Biochem Biophys Res Commun 289,
457-462 (2001).
22 Hirasawa, A., Awaji, T., Xu, Z., Shinoura, H. & Tsujimoto, G. Regulation
of subcellular localization of alpha1-adrenoceptor subtypes. Life Sci 68,
2259-2267 (2001).
23 Ogata, M., Awaji, T., Iwasaki, N., Miyazaki, S., Bell, G. I. & Iwamoto,
Y. Nuclear translocation of SHP and visualization of interaction with HNF-4alpha
in living cells. Biochem Biophys Res Commun 292, 8-12 (2002).
24 Yoda, A., Oda, S., Shikano, T., Kouchi, Z., Awaji, T., Shirakawa, H.,
Kinoshita, K. & Miyazaki, S. Ca2+ oscillation-inducing phospholipase
C zeta expressed in mouse eggs is accumulated to the pronucleus during
egg activation. Dev Biol 268, 245-257 (2004).
25 Hirasawa, A., Tsumaya, K., Awaji, T., Katsuma, S., Adachi, T., Yamada,
M., Sugimoto, Y., Miyazaki, S. & Tsujimoto, G. Free fatty acids regulate
gut incretin glucagon-like peptide-1 secretion through GPR120. Nat Med
11, 90-94 (2005).
26 Kuroda, K., Ito, M., Shikano, T., Awaji, T., Yoda, A., Takeuchi, H.,
Kinoshita, K. & Miyazaki, S. The role of X/Y linker region and N-terminal
EF-hand domain in nuclear translocation and Ca2+ oscillation-inducing activities
of phospholipase Czeta, a mammalian egg-activating factor. J Biol Chem
281, 27794-27805 (2006).
27 Ito, M., Shikano, T., Oda, S., Horiguchi, T., Tanimoto, S., Awaji, T.,
Mitani, H. & Miyazaki, S. Difference in Ca2+ oscillation-inducing activity
and nuclear translocation ability of PLCZ1, an egg-activating sperm factor
candidate, between mouse, rat, human, and medaka fish. Biol Reprod 78,
1081-1090 (2008).
28 Hara, T., Hirasawa, A., Sun, Q., Koshimizu, T. A., Itsubo, C., Sadakane,
K., Awaji, T. & Tsujimoto, G. Flow cytometry-based binding assay for
GPR40 (FFAR1; free fatty acid receptor 1). Mol Pharmacol 75, 85-91 (2009).
29 Sun, Q., Hirasawa, A., Hara, T., Kimura, I., Adachi, T., Awaji, T.,
Ishiguro, M., Suzuki, T., Miyata, N. & Tsujimoto, G. Structure-activity
relationships of GPR120 agonists based on a docking simulation. Mol Pharmacol
78, 804-810 (2010).
30 Ogata, M., Awaji, T., Iwasaki, N., Fujimaki, R., Takizawa, M., Maruyama,
K., Iwamoto, Y. & Uchigata, Y. A new mitochondrial pH biosensor for
quantitative assessment of pancreatic beta-cell function. Biochem Biophys
Res Commun 421, 20-26 (2012).
31 Takeuchi, M., Hirasawa, A., Hara, T., Kimura, I., Hirano, T., Suzuki,
T., Miyata, N., Awaji, T., Ishiguro, M. & Tsujimoto, G. FFA1-selective
agonistic activity based on docking simulation using FFA1 and GPR120 homology
models. Br J Pharmaco, 168(7):1570-83(2013).