原著論文
Iwasa K, Yagishita S, Yagishita-Kyo N, Yamagishi A, Yamamoto S, Yamashina
K, Haruta C, Asai M, Maruyama K, Shimizu K, Yoshikawa K
Long term administration of loquat leaves and their major component, ursolic
acid, attenuated endogenous amyloid-β burden and memory impairment
Scientific Reports. 2023 Oct 5;13(1):16770. PMID: 37798424
Yamamoto S, Iwasa K, Yamagishi A, Haruta C, Maruyama K, Yoshikawa K
Microglial depletion exacerbates axonal damage and motor dysfunction in
mice with cuprizone-induced demyelination.
Journal of Pharmacological Sciences. 2023 Nov;153(3):94-103. PMID: 37770161
Igarashi M, Iwasa K, Hayakawa T, Tsuduki T, Kimura I, Maruyama K, Yoshikawa
K.
Dietary oleic acid contributes to the regulation of food intake through
the synthesis of intestinal oleoylethanolamide.
Front Endocrinol (Lausanne). 2023 Jan 17;13:1056116. PMID: 36733808
Iwasa K, Yamagishi A, Yamamoto S, Haruta C, Maruyama K, Yoshikawa K
GPR137 inhibits cell proliferation and promotes neuronal differentiation
in the Neuro2A cells
Neurochemical Research 2022 Mar;48(3):996-1008. PMID: 36436172
Yamashina K, Yamamoto S, Matsumoto M, Iwasa K, Takeda N, Haruta C, Maruyama
K, Shimizu K, Yoshikawa K.
Suppressive Effect of Fruiting Bodies of Medicinal Mushrooms on Demyelination
and Motor Dysfunction in a Cuprizone-Induced Multiple Sclerosis Mouse Model.
Int J Med Mushrooms. 2022;24(9):15-24. doi: 10.1615/IntJMedMushrooms.2022044840.
PMID: 36004706
Iwasa K, Yamamoto S, Yamashina K, Yagishita-Kyo N, Maruyama K, Awaji T,
Takei Y, Hirasawa A, Yoshikawa K.
A peripheral lipid sensor GPR120 remotely contributes to suppression of
PGD2-microglia-provoked neuroinflammation and neurodegeneration in the
mouse hippocampus.
J Neuroinflammation. 2021 Dec 27;18(1):304. doi: 10.1186/s12974-021-02361-2.
PMID: 34961526
Yagishita-Kyo N, Ikai Y, Uekita T, Shinohara A, Koshimoto C, Yoshikawa
K, Maruyama K, Yagishita S.
Testosterone interrupts binding of Neurexin and Neuroligin that are expressed
in a highly socialized rodent, Octodon degus.
Biochem Biophys Res Commun. 2021 Apr 30;551:54-62. doi: 10.1016/j.bbrc.2021.03.015.
Epub 2021 Mar 12. PMID: 33721831
Fukasawa K, Gotoh M, Uwamizu A, Hirokawa T, Ishikawa M, Shimizu Y, Yamamoto
S, Iwasa K, Yoshikawa K, Aoki J, Gotoh M, Murakami-Murofushi K
2-Carba-lysophosphatidic acid is a novel β-lysophosphatidic acid analogue
with high potential for lysophosphatidic acid receptor activation and autotaxin
inhibition
Scientific Reports 2021 11:17360 PMID: 34462512
Igarashi M, Iwasa K, Yoshikawa K.
Feeding regulation by oleoylthanolamide synthesized from dietary oleic
acid Prostaglandins, Leukotrienes and Essential Fatty Acids 2021 165:102228
PMID: 33385936.
Yamamoto S, Sakemoto C, Iwasa K, Maruyama K, Shimizu K, Yoshikawa K.
Ursolic acid treatment suppresses cuprizone-induced demyelination and motor
dysfunction via upregulation of IGF-1.
J Pharmacol Sci. 2020 Nov;144(3):119-122. doi: 10.1016/j.jphs.2020.08.002.
Epub 2020 Aug 19. PMID:32921392
Shimizu Y, Fukasawa K, Yamamoto S, Shibaike Y, Tsukahara R, Ishikawa M,
Iwasa K, Yoshikawa K, Gotoh M, Murakami-Murofushi K.
Evaluation of the pharmacokinetics of 2-carba-cyclic phosphatidic acid
by liquid chromatography-triple quadrupole mass spectrometry
Prostaglandin and Other Lipid Mediators. 2020. 150:106450 PMID: 32298781.
Seki T, Kanagawa M, Kobayashi K, Kowa H, Yahata N, Maruyama K, Iwata N,
Inoue H, Toda T.
Galectin 3-binding protein suppresses amyloid-β production by modulating
β-cleavage of amyloid precursor protein.
J Biol Chem. 2020 Mar 13;295(11):3678-3691. doi: 10.1074/jbc.RA119.008703.
Epub 2020 Jan 29. PMID:31996371
Suo S, Harada K, Matsuda S, Kyo K, Wang M, Maruyama K, Awaji T, Tsuboi
T.
Sexually Dimorphic Regulation of Behavioral States by Dopamine in Caenorhabditis
elegans.
J Neurosci. 2019 Jun 12;39(24):4668-4683. doi: 10.1523/JNEUROSCI.2985-18.2019.
Epub 2019 Apr 15. PMID: 30988167
Shibaike Y, Gotoh M, Ogawa C, Nagajima S, Yoshikawa K, Kobayashi T, Murakami-Murofushi
K.
2-Carba cyclic phosphatidic acid inhibits lipopolysaccharide-induced prostaglandin
E2 production in a human macrophage cell line
Biochemistry and Biophysics Reports. 2019. 19:100668 PMID:31367683.
Shimizu Y, Ishikawa M, Gotoh M, Fukasawa K, Yamamoto S, Iwasa K, Yoshikawa
K, Murakami-Murofushi K.
Quantitative determination of cyclic phosphatidic acid and its carba analog
in mouse organs and plasma using LC–MS/MS.
Journal of Chromatography B. 2018. 1076:15-21 PMID:29353671
Tsukahara R, Yamamoto S, Yoshikawa K, Gotoh M, Tsukahara T, Neyama H, Ishii
S, Akahoshi N, Yanagida K, Sumida H, Araki M, Araki K, Yamamura K, Murakami-Murofushi
K, Ueda H.
LPA5 Signaling is involved in Multiple Sclerosis-mediated Neuropathic Pain
in the Cuprizone Mouse Model.
Journal of Pharmacological Sciences. 2018. 136(2) :93-96 PMID: 29409686.
Hashimoto M, Yamamoto S, Iwasa K, Yamashina K, Ishikawa M, Maruyama K,
Bosetti F, Yoshikawa K.
The flavonoid Baicalein attenuates cuprizone-induced demyelination via
suppression of neuroinflammation.
Brain Res Bull. 2017. Oct;135:47-52. doi: 10.1016/j.brainresbull.2017.09.007.
Epub 2017 Sep 15. PMID: 28923306
Yamamoto S, Yamashina K, Ishikawa M, Gotoh M, Yagishita S, Iwasa K, Maruyama
K, Murakami-Murofushi K, Yoshikawa K.
Protective and therapeutic role of 2-carba-cyclic phosphatidic acid in
demyelinating disease.
J Neuroinflammation. 2017 Jul 21;14(1):142. doi: 10.1186/s12974-017-0923-5.
PMID: 28732510
Iwasa K, Yamamoto S, Yagishita S, Maruyama K, Yoshikawa K.
Excitotoxicity-induced immediate prostaglandin D2 production induces sustained
microglial activation and delayed neuronal death in the hippocampus.
J Lipid Res. 2017 Feb 7. pii: jlr.M070532. doi: 10.1194/jlr.M070532. PubMed
PMID: 28174214.
Yagishita S, Suzuki S, Yoshikawa K, Iida K, Hirata A, Suzuki M, Takashima
A, Maruyama K, Hirasawa A, Awaji T.
Treatment of intermittent hypoxia increases phosphorylated tau in the hippocampus
via biological processes common to aging.
Mol Brain. 2017 Jan 5;10(1):2. doi: 10.1186/s13041-016-0282-7. PMID:28057021
Asai M, Kinjo A, Kimura S, Mori R, Kawakubo T, Shirotani K, Yagishita S,
Maruyama K, Iwata N.
Perturbed Calcineurin-NFAT Signaling Is Associated with the Development
of Alzheimer's Disease.
Biol Pharm Bull. 2016;39(10):1646-1652. PMID: 27725441.
Yagishita S, Murayama M, Ebihara T, Maruyama K, Takashima A.
Glycogen Synthase Kinase 3β-mediated Phosphorylation in the Most C-terminal
Region of Protein
Interacting with C Kinase 1 (PICK1) Regulates the Binding of PICK1 to Glutamate
Receptor Subunit GluA2.
J Biol Chem. 2015 Dec 4;290(49):29438-48. doi:10.1074/jbc.M114.619668.
PMID: 26472923.
Iwasa K, Yamamoto S, Takahashi M, Suzuki S, Yagishita S, Awaji T, Maruyama
K, Yoshikawa K.
Prostaglandin F 2α FP receptor inhibitor reduces demyelination and motor
dysfunction in a cuprizone-induced multiple sclerosis mouse model.
Prostaglandins, Leukotrienes and Essential Fatty Acids. 2014 91:175-182
PMID: 25224839.
Yamamoto S, Gotoh M, Kawamura Y, Yamashina K, Yagishita S, Awaji T, Tanaka
M, Maruyama K, Murakami-Murofushi K, Yoshikawa K.
Cyclic phosphatidic acid treatment suppress cuprizone-induced demyelination
and motor dysfunction in mice.
Eur J Pharmacol. 2014 Oct 15;741:17-24. doi: 10.1016/j.ejphar.2014.07.040.
PMID:25084219.
Yoshikawa K, Kita Y, Furukawa A, Kawamura N, Hasegawa-Ishii S, Chiba Y,
Takei S, Maruyama K, Shimizu T, Shimada A.
Excitotoxicity-induced immediate surge in hippocampal prostanoid production
has latent effects that promote chronic progressive neuronal death.
Prostaglandins, Leukotrienes and Essential Fatty Acids. 2013 May;88(5):373-81.
doi:10.1016/j.plefa.2013.02.007. PMID: 23528866.
Kondo T, Asai M, Tsukita K, Kutoku Y, Ohsawa Y, Sunada Y, Imamura K, Egawa
N, Yahata N, Okita K, Takahashi K, Asaka I, Aoi T, Watanabe A, Watanabe
K, Kadoya C, Nakano R, Watanabe D, Maruyama K, Hori O, Hibino S, Choshi
T, Nakahata T, Hioki H, Kaneko T, Naitoh M, Yoshikawa K, Yamawaki S, Suzuki
S, Hata R, Ueno S, Seki T, Kobayashi K, Toda T, Murakami K, Irie K, Klein
WL, Mori H, Asada T, Takahashi R, Iwata N, Yamanaka S, Inoue H.
Modeling Alzheimer's disease with iPSCs reveals stress phenotypes associated
with intracellular Aβ and differential drug responsiveness.
Cell Stem Cell. 2013 Apr 4;12(4):487-96. doi:10.1016/j.stem.2013.01.009.
PMID: 23434393.
Ogata M, Awaji T, Iwasaki N, Fujimaki R, Takizawa M, Maruyama K, Bell GI,
Iwamoto Y, Uchigata Y.
Localization of hepatocyte nuclear factor-4α in the nucleolus and nucleus
is regulated by its C-terminus.
J Diabetes Investig. 2012 Oct 18;3(5):449-56. doi: 10.1111/j.2040-1124.2012.00210.x.
PMID: 24843605.
Ogata M, Awaji T, Iwasaki N, Fujimaki R, Takizawa M, Maruyama K, Iwamoto
Y, Uchigata Y.
A new mitochondrial pH biosensor for quantitative assessment of pancreatic
β-cell function.
Biochem Biophys Res Commun. 2012 Apr 27;421(1):20-6. doi: 10.1016/j.bbrc.2012.03.093.
PMID: 22465007.
Yoshikawa K, Palumbo S, Toscano CD, Bosetti F.
Inhibition of 5-lipoxygenase activity in mice during cuprizone-induced
demyelination attenuates neuroinflammation, motor dysfunction and axonal
damage.
Prostaglandins, Leukotrienes and Essential Fatty Acids 2011 85(1):43-52
PMID:21555210.
Yoshikawa K, Takei S, Hasegawa-Ishii S, Chiba Y, Furukawa A, Kawamura N,
Hosokawa M, Woodward DF, Watanabe K, Shimada A.
Preferential localization of prostamide/prostaglandin F synthase in myelin
sheaths of the central nervous system.
Brain Research 2011 1367: 22-32 PMID:20950588.
Yahata N, Asai M, Kitaoka S, Takahashi K, Asaka I, Hioki H, Kaneko T, Maruyama
K, Saido TC, Nakahata T, Asada T, Yamanaka S, Iwata N, Inoue H.
Anti-Aβ drug screening platform using human iPS cell-derived neurons for
the treatment of Alzheimer's disease.
PLoS One. 2011;6(9):e25788. doi:10.1371/journal.pone.0025788. PMID: 21984949.
Asai M, Yagishita S, Iwata N, Saido TC, Ishiura S, Maruyama K.
An alternative metabolic pathway of amyloid precursor protein C-terminal
fragments via cathepsin B in a human neuroglioma model.
FASEB J. 2011 Oct;25(10):3720-30. doi:10.1096/fj.11-182154. PMID: 21746863.
Sun X, Iida S, Yoshikawa A, Senbonmatsu R, Imanaka K, Maruyama K, Nishimura
S, Inagami T, Senbonmatsu T.
Non-activated APJ suppresses the angiotensin II type 1 receptor, whereas
apelin-activated APJ acts conversely.
Hypertens Res. 2011 Jun;34(6):701-6. doi: 10.1038/hr.2011.19. PMID: 21412239.
Durairajan SS, Liu LF, Lu JH, Koo I, Maruyama K, Chung SK, Huang JD, Li
M.
Stimulation of non-amyloidogenic processing of amyloid-β protein precursor
by cryptotanshinone involves activation and translocation of ADAM10 and
PKC-α.
J Alzheimers Dis. 2011;25(2):245-62. doi: 10.3233/JAD-2011-102085. PMID:21403388.
Asai M, Iwata N, Tomita T, Iwatsubo T, Ishiura S, Saido TC, Maruyama K.
Efficient four-drug cocktail therapy targeting amyloid-β peptide for Alzheimer's
disease.
J Neurosci Res. 2010 Dec;88(16):3588-97. doi: 10.1002/jnr.22503. PMID:
20890992.
Aizaki Y, Maruyama K, Nakano-Tetsuka M, Saito Y.
Distinct roles of the DRY motif in rat melanin-concentrating hormone receptor
1 in signaling control.
Peptides. 2009 May;30(5):974-81. doi: 10.1016/j.peptides.2009.01.017. PMID:
19428776.
Miyamoto-Matsubara M, Saitoh O, Maruyama K, Aizaki Y, Saito Y.
Regulation of melanin-concentrating hormone receptor 1 signaling by RGS8
with the receptor third intracellular loop.
Cell Signal. 2008 Nov;20(11):2084-94. doi:10.1016/j.cellsig.2008.07.019.
PMID: 18760349.
Asai M, Iwata N, Yoshikawa A, Aizaki Y, Ishiura S, Saido TC, Maruyama K.
Berberine alters the processing of Alzheimer's amyloid precursor protein
to decrease Abeta secretion.
Biochem Biophys Res Commun. 2007 Jan 12;352(2):498-502. PMID: 17125739.
Tanabe C, Hotoda N, Sasagawa N, Sehara-Fujisawa A, Maruyama K, Ishiura
S.
ADAM19 is tightly associated with constitutive Alzheimer's disease APP
alpha-secretase in A172 cells.
Biochem Biophys Res Commun. 2007 Jan 5;352(1):111-7. PMID: 17112471.
Saito Y, Maruyama K.
Identification of melanin-concentrating hormone receptor and its impact
on drug discovery.
J Exp Zool A Comp Exp Biol. 2006 Sep 1;305(9):761-8. Review. PMID: 16902961.
Hattori C, Asai M, Onishi H, Sasagawa N, Hashimoto Y, Saido TC, Maruyama
K, Mizutani S, Ishiura S.
BACE1 interacts with lipid raft proteins.
J Neurosci Res.2006 Sep;84(4):912-7. PMID: 16823808.
Yoshikawa A, Saito Y, Maruyama K.
Lignan compounds and 4,4'-dihydroxybiphenyl protect C2C12 cells against
damage from oxidative stress.
Biochem Biophys Res Commun. 2006 May 26;344(1):394-9. PMID: 16616009.
Nakagawa K, Kitazume S, Oka R, Maruyama K, Saido TC, Sato Y, Endo T, Hashimoto
Y.
Sialylation enhances the secretion of neurotoxic amyloid-beta peptides.
J Neurochem. 2006 Feb;96(4):924-33. PMID: 16412100.
Asai M, Hattori C, Iwata N, Saido TC, Sasagawa N, Szabó B, Hashimoto Y,
Maruyama K, Tanuma S, Kiso Y, Ishiura S.
The novel beta-secretase inhibitor KMI-429 reduces amyloid beta peptide
production in amyloid precursor protein transgenic and wild-type mice.
J Neurochem. 2006 Jan;96(2):533-40. PMID:16336629.
Li Y, Saito Y, Suzuki M, Ueda H, Endo M, Maruyama K.
Kyotorphin has a novel action on rat cardiac muscle.
Biochem Biophys Res Commun. 2006 Jan 20;339(3):805-9. PMID: 16325776.
Tanaka M, Maruyama K.
Mechanisms of capsaicin- and citric-acid-induced cough reflexes in guinea
pigs.
J Pharmacol Sci. 2005 Sep;99(1):77-82. PMID:16127241.
Saito Y, Tetsuka M, Saito S, Imai K, Yoshikawa A, Doi H, Maruyama K.
Arginine residue 155 in the second intracellular loop plays a critical
role in rat melanin-concentrating hormone receptor 1 activation.
Endocrinology. 2005 Aug;146(8):3452-62. PMID: 15890773.
Saito Y, Tetsuka M, Li Y, Kurose H, Maruyama K.
Properties of rat melanin-concentrating hormone receptor 1 internalization.
Peptides. 2004 Oct;25(10):1597-604. PMID: 15476926.
Tetsuka M, Saito Y, Imai K, Doi H, Maruyama K.
The basic residues in the membrane-proximal C-terminal tail of the rat
melanin-concentrating hormone receptor 1 are required for receptor function.
Endocrinology. 2004 Aug;145(8):3712-23. PMID: 15117878.
Suzuki M, Nishina M, Nakamura S, Maruyama K.
Benzodiazepine-sensitive GABA(A) receptors in the commissural subnucleus
of the NTS are involved in the carotid chemoreceptor reflex in rats.
Auton Neurosci. 2004 Feb 27;110(2):108-13. PMID: 15046734.
Hosoya T, Hiramatsu T, Ikemoto T, Nakanishi M, Aoyama H, Hosoya A, Iwata
T, Maruyama K, Endo M, Suzuki M.
Novel bifunctional probe for radioisotope-free photoaffinity labeling:
compact structure comprised of photospecific ligand ligation and detectable
tag anchoring units.
Org Biomol Chem. 2004 Mar 7;2(5):637-41. PMID: 14985799.
Kasai H, Yao A, Oyama T, Hasegawa H, Akazawa H, Toko H, Nagai T, Kinugawa
K, Kohmoto O, Maruyama K, Takahashi T, Nagai R, Miyawaki A, Komuro I.
Direct measurement of Ca2+ concentration in the SR of living cardiac myocytes.
Biochem Biophys Res Commun. 2004 Feb 20;314(4):1014-20. PMID: 14751234.
Tanaka M, Maruyama K.
Cough reflex induced by microinjection of citric acid into the larynx of
guinea pigs: new coughing model.
J Pharmacol Sci. 2003 Dec;93(4):465-70. PMID: 14737018.
Kume H, Maruyama K, Kametani F.
Intracellular domain generation of amyloid precursor protein by epsilon-cleavage
depends on C-terminal fragment by alpha-secretase cleavage.
Int J Mol Med. 2004 Jan;13(1):121-5. PMID:14654982.
Inoue R, Tanabe M, Kono K, Maruyama K, Ikemoto T, Endo M.
Ca2+-releasing effect of cerivastatin on the sarcoplasmic reticulum of
mouse and rat skeletal muscle fibers.
J Pharmacol Sci. 2003 Nov;93(3):279-88. PMID: 14646245.
Kume H, Sekijima Y, Maruyama K, Kametani F.
gamma-Secretase can cleave amyloid precursor protein fragments independent
of alpha- and beta-secretase pre-cutting.
Int J Mol Med. 2003 Jul;12(1):57-60. PMID: 12792809.
Asai M, Hattori C, Szabó B, Sasagawa N, Maruyama K, Tanuma S, Ishiura S.
Putative function of ADAM9, ADAM10, and ADAM17 as APP alpha-secretase.
Biochem Biophys Res Commun. 2003 Jan 31;301(1):231-5. PMID: 12535668.
Saito Y, Tetsuka M, Yue L, Kawamura Y, Maruyama K.
Functional role of N-linked glycosylation on the rat melanin-concentrating
hormone receptor 1. FEBS Lett.
2003 Jan 2;533(1-3):29-34. PMID: 12505154.
Shirotani K, Tsubuki S, Lee HJ, Maruyama K, Saido TC.
Generation of amyloid beta peptide with pyroglutamate at position 3 in
primary cortical neurons.
Neurosci Lett. 2002 Jul 12;327(1):25-8. PMID: 12098492.
Hattori C, Asai M, Oma Y, Kino Y, Sasagawa N, Saido TC, Maruyama K, Ishiura
S.
BACE1 interacts with nicastrin.
Biochem Biophys Res Commun. 2002 May 17;293(4):1228-32. PMID: 12054507.
Shizuka-Ikeda M, Matsubara E, Ikeda M, Kanai M, Tomidokoro Y, Ikeda Y,
Watanabe M, Kawarabayashi T, Harigaya Y, Okamoto K, Maruyama K, Castaño
EM, St. George-Hyslop P, Shoji M.
Generation of amyloid beta protein from a presenilin-1and betaAPP complex.
Biochem Biophys Res Commun. 2002 Mar 29;292(2):571-8. PMID: 11906199.
Westerman BA, Poutsma A, Maruyama K, Schrijnemakers HF, van Wijk IJ, Oudejans
CB.
The proneural genes NEUROD1 and NEUROD2 are expressed during human trophoblast
invasion.
Mech Dev. 2002 Apr;113(1):85-90. PMID: 11900979.
日本語総説
カテプシンBを介したアミロイド前駆体タンパク質の代謝経路
柳下聡介, 浅井将, 岩田修永, 西道隆臣, 石浦章一, 丸山敬
日本薬理学会部会(日本薬理学雑誌) 141(1): 12-12, 2013.
加齢性神経変性モデルSAMP10脳における脂質メディエーターの網羅的定量解析
吉川圭介, 北芳博, 島田厚良, 清水孝雄, 丸山敬
日本薬理学会部会(日本薬理学雑誌) 140(4): 14-14, 2012.培養膵β生細胞ミトコンドリア機能
尾形真規子, 岩崎直子, 淡路健雄, 丸山敬, 岩本安彦
日本内分泌学会雑誌 87(1): 280-280, 2011.
Angiotennsin converting enzyme inhibitor(ACEI)の心保護作用
相崎良美, 吉河歩, 飯田慎一郎, 加藤誠, 孫驍, 丸山敬, 村松俊裕, 松村誠, 西村重敬, 千本松孝明
日本内分泌学会雑誌 85(2): 724-724, 2009.
既存薬物によるアルツハイマー病への応用
浅井将, 岩田修永, 西道隆臣, 丸山敬
日本薬理学会部会(日本薬理学会雑誌) 132(2): 5-5, 2008.
Angiotensin IIによるJAK2キナーゼを介するPLZFチロシンリン酸化の解析
千本松孝明, 吉河歩, 丸山敬
日本薬理学会部会(日本薬理学会雑誌) 129(1): 12-12, 2007.
オーフアンGPCRとうつ病
斎藤祐見子, Zhiwei Wang, 丸山敬
日本薬理学雑誌 127(3): 190-195, 2006.
Kyotorphin has a novel action on rat cardiac muscle
李月, 斎藤裕見子, 鈴木正彦, 植田弘師, 丸山敬
Folia Pharmacologica Japonica 124(2): 5003-5003, 2004.
摂食とメラニン凝集ホルモン(melanin-concentrating hormone:MCH)
斎藤祐見子, 丸山敬
日本内分泌学会雑誌 79(1): 22-22, 2003.
モルモットの喉頭へのクエン酸微量注入による咳誘発モデル
田中求, 河本定則, 丸山敬
日本薬理学雑誌 120(4): 237-243, 2002.
Alzheimer病モデルマウス
丸山敬
医学のあゆみ 203(11): 999-1003, 2002.
新規のアルツハイマー病アミロイド前駆体蛋白質代謝因子の検索
丸山敬, 宇佐美美穂子
日本薬理学雑誌 117(3): 59-59, 2001.