業績

原著論文

Yamamoto S, Yamashina K, Ishikawa M, Gotoh M, Yagishita S, Iwasa K, Maruyama K, Murakami-Murofushi K, Yoshikawa K. Protective and therapeutic role of 2-carba-cyclic phosphatidic acid in demyelinating disease. J Neuroinflammation. 2017 Jul 21;14(1):142. doi: 10.1186/s12974-017-0923-5.
PMID: 28732510

Iwasa K, Yamamoto S, Yagishita S, Maruyama K, Yoshikawa K.
Excitotoxicity-induced immediate prostaglandin D2 production induces sustained
microglial activation and delayed neuronal death in the hippocampus. J Lipid Res.
2017 Feb 7. pii: jlr.M070532. doi: 10.1194/jlr.M070532. PubMed PMID: 28174214.

Yagishita S, Suzuki S, Yoshikawa K, Iida K, Hirata A, Suzuki M, Takashima A,
Maruyama K, Hirasawa A, Awaji T. Treatment of intermittent hypoxia increases
phosphorylated tau in the hippocampus via biological processes common to aging.
Mol Brain. 2017 Jan 5;10(1):2. doi: 10.1186/s13041-016-0282-7. PubMed PMID:
28057021解説はこちら

Asai M, Kinjo A, Kimura S, Mori R, Kawakubo T, Shirotani K, Yagishita S, Maruyama K, Iwata N. Perturbed Calcineurin-NFAT Signaling Is Associated with the Development of Alzheimer's Disease. Biol Pharm Bull. 2016;39(10):1646-1652.
PubMed PMID: 27725441.

Yagishita S, Murayama M, Ebihara T, Maruyama K, Takashima A. Glycogen Synthase Kinase 3β-mediated Phosphorylation in the Most C-terminal Region of Protein Interacting with C Kinase 1 (PICK1) Regulates the Binding of PICK1 to Glutamate Receptor Subunit GluA2. J Biol Chem. 2015 Dec 4;290(49):29438-48. doi:10.1074/jbc.M114.619668. PubMed PMID: 26472923.

Yamamoto S, Gotoh M, Kawamura Y, Yamashina K, Yagishita S, Awaji T, Tanaka M,
Maruyama K, Murakami-Murofushi K, Yoshikawa K. Cyclic phosphatidic acid treatment
suppress cuprizone-induced demyelination and motor dysfunction in mice. Eur J
Pharmacol. 2014 Oct 15;741:17-24. doi: 10.1016/j.ejphar.2014.07.040. PubMed PMID:25084219.

Yoshikawa K, Kita Y, Furukawa A, Kawamura N, Hasegawa-Ishii S, Chiba Y, Takei
S, Maruyama K, Shimizu T, Shimada A. Excitotoxicity-induced immediate surge in
hippocampal prostanoid production has latent effects that promote chronic
progressive neuronal death. Prostaglandins Leukot Essent Fatty Acids. 2013
May;88(5):373-81. doi: 10.1016/j.plefa.2013.02.007. PubMed PMID: 23528866.

Kondo T, Asai M, Tsukita K, Kutoku Y, Ohsawa Y, Sunada Y, Imamura K, Egawa N,
Yahata N, Okita K, Takahashi K, Asaka I, Aoi T, Watanabe A, Watanabe K, Kadoya C,
Nakano R, Watanabe D, Maruyama K, Hori O, Hibino S, Choshi T, Nakahata T, Hioki
H, Kaneko T, Naitoh M, Yoshikawa K, Yamawaki S, Suzuki S, Hata R, Ueno S, Seki T,
Kobayashi K, Toda T, Murakami K, Irie K, Klein WL, Mori H, Asada T, Takahashi R,
Iwata N, Yamanaka S, Inoue H. Modeling Alzheimer's disease with iPSCs reveals
stress phenotypes associated with intracellular Aβ and differential drug
responsiveness. Cell Stem Cell. 2013 Apr 4;12(4):487-96. doi:
10.1016/j.stem.2013.01.009. PubMed PMID: 23434393.

Ogata M, Awaji T, Iwasaki N, Fujimaki R, Takizawa M, Maruyama K, Bell GI,
Iwamoto Y, Uchigata Y. Localization of hepatocyte nuclear factor-4α in the
nucleolus and nucleus is regulated by its C-terminus. J Diabetes Investig. 2012
Oct 18;3(5):449-56. doi: 10.1111/j.2040-1124.2012.00210.x. PubMed PMID: 24843605.

Ogata M, Awaji T, Iwasaki N, Fujimaki R, Takizawa M, Maruyama K, Iwamoto Y,
Uchigata Y. A new mitochondrial pH biosensor for quantitative assessment of
pancreatic β-cell function. Biochem Biophys Res Commun. 2012 Apr 27;421(1):20-6.
doi: 10.1016/j.bbrc.2012.03.093. PubMed PMID: 22465007.

Yahata N, Asai M, Kitaoka S, Takahashi K, Asaka I, Hioki H, Kaneko T,
Maruyama K, Saido TC, Nakahata T, Asada T, Yamanaka S, Iwata N, Inoue H. Anti-Aβ
drug screening platform using human iPS cell-derived neurons for the treatment of
Alzheimer's disease. PLoS One. 2011;6(9):e25788. doi:
10.1371/journal.pone.0025788. PubMed PMID: 21984949.

Asai M, Yagishita S, Iwata N, Saido TC, Ishiura S, Maruyama K. An alternative
metabolic pathway of amyloid precursor protein C-terminal fragments via cathepsin
B in a human neuroglioma model. FASEB J. 2011 Oct;25(10):3720-30. doi:
10.1096/fj.11-182154. PubMed PMID: 21746863.

Sun X, Iida S, Yoshikawa A, Senbonmatsu R, Imanaka K, Maruyama K, Nishimura
S, Inagami T, Senbonmatsu T. Non-activated APJ suppresses the angiotensin II type
1 receptor, whereas apelin-activated APJ acts conversely. Hypertens Res. 2011
Jun;34(6):701-6. doi: 10.1038/hr.2011.19. PubMed PMID: 21412239.

Durairajan SS, Liu LF, Lu JH, Koo I, Maruyama K, Chung SK, Huang JD, Li M.
Stimulation of non-amyloidogenic processing of amyloid-β protein precursor by
cryptotanshinone involves activation and translocation of ADAM10 and PKC-α. J
Alzheimers Dis. 2011;25(2):245-62. doi: 10.3233/JAD-2011-102085. PubMed PMID:
21403388.

Asai M, Iwata N, Tomita T, Iwatsubo T, Ishiura S, Saido TC, Maruyama K.
Efficient four-drug cocktail therapy targeting amyloid-β peptide for Alzheimer's
disease. J Neurosci Res. 2010 Dec;88(16):3588-97. doi: 10.1002/jnr.22503. PubMed
PMID: 20890992.

Aizaki Y, Maruyama K, Nakano-Tetsuka M, Saito Y. Distinct roles of the DRY
motif in rat melanin-concentrating hormone receptor 1 in signaling control.
Peptides. 2009 May;30(5):974-81. doi: 10.1016/j.peptides.2009.01.017. PubMed
PMID: 19428776.

Miyamoto-Matsubara M, Saitoh O, Maruyama K, Aizaki Y, Saito Y. Regulation of
melanin-concentrating hormone receptor 1 signaling by RGS8 with the receptor
third intracellular loop. Cell Signal. 2008 Nov;20(11):2084-94. doi:
10.1016/j.cellsig.2008.07.019. PubMed PMID: 18760349.

Asai M, Iwata N, Yoshikawa A, Aizaki Y, Ishiura S, Saido TC, Maruyama K.
Berberine alters the processing of Alzheimer's amyloid precursor protein to
decrease Abeta secretion. Biochem Biophys Res Commun. 2007 Jan 12;352(2):498-502.
PubMed PMID: 17125739.

Tanabe C, Hotoda N, Sasagawa N, Sehara-Fujisawa A, Maruyama K, Ishiura S.
ADAM19 is tightly associated with constitutive Alzheimer's disease APP
alpha-secretase in A172 cells. Biochem Biophys Res Commun. 2007 Jan
5;352(1):111-7. PubMed PMID: 17112471.

Saito Y, Maruyama K. Identification of melanin-concentrating hormone receptor
and its impact on drug discovery. J Exp Zool A Comp Exp Biol. 2006 Sep
1;305(9):761-8. Review. PubMed PMID: 16902961.

Hattori C, Asai M, Onishi H, Sasagawa N, Hashimoto Y, Saido TC, Maruyama K,
Mizutani S, Ishiura S. BACE1 interacts with lipid raft proteins. J Neurosci Res.
2006 Sep;84(4):912-7. PubMed PMID: 16823808.

Yoshikawa A, Saito Y, Maruyama K. Lignan compounds and 4,4'-dihydroxybiphenyl
protect C2C12 cells against damage from oxidative stress. Biochem Biophys Res
Commun. 2006 May 26;344(1):394-9. PubMed PMID: 16616009.

Nakagawa K, Kitazume S, Oka R, Maruyama K, Saido TC, Sato Y, Endo T,
Hashimoto Y. Sialylation enhances the secretion of neurotoxic amyloid-beta
peptides. J Neurochem. 2006 Feb;96(4):924-33. PubMed PMID: 16412100.

Asai M, Hattori C, Iwata N, Saido TC, Sasagawa N, Szabó B, Hashimoto Y,
Maruyama K, Tanuma S, Kiso Y, Ishiura S. The novel beta-secretase inhibitor
KMI-429 reduces amyloid beta peptide production in amyloid precursor protein
transgenic and wild-type mice. J Neurochem. 2006 Jan;96(2):533-40. PubMed PMID:
16336629.

Li Y, Saito Y, Suzuki M, Ueda H, Endo M, Maruyama K. Kyotorphin has a novel
action on rat cardiac muscle. Biochem Biophys Res Commun. 2006 Jan
20;339(3):805-9. PubMed PMID: 16325776.

Tanaka M, Maruyama K. Mechanisms of capsaicin- and citric-acid-induced cough
reflexes in guinea pigs. J Pharmacol Sci. 2005 Sep;99(1):77-82. PubMed PMID:
16127241.

Saito Y, Tetsuka M, Saito S, Imai K, Yoshikawa A, Doi H, Maruyama K. Arginine
residue 155 in the second intracellular loop plays a critical role in rat
melanin-concentrating hormone receptor 1 activation. Endocrinology. 2005
Aug;146(8):3452-62. PubMed PMID: 15890773.

Saito Y, Tetsuka M, Li Y, Kurose H, Maruyama K. Properties of rat
melanin-concentrating hormone receptor 1 internalization. Peptides. 2004
Oct;25(10):1597-604. PubMed PMID: 15476926.

Tetsuka M, Saito Y, Imai K, Doi H, Maruyama K. The basic residues in the
membrane-proximal C-terminal tail of the rat melanin-concentrating hormone
receptor 1 are required for receptor function. Endocrinology. 2004
Aug;145(8):3712-23. PubMed PMID: 15117878.

Suzuki M, Nishina M, Nakamura S, Maruyama K. Benzodiazepine-sensitive GABA(A)
receptors in the commissural subnucleus of the NTS are involved in the carotid
chemoreceptor reflex in rats. Auton Neurosci. 2004 Feb 27;110(2):108-13. PubMed
PMID: 15046734.

Hosoya T, Hiramatsu T, Ikemoto T, Nakanishi M, Aoyama H, Hosoya A, Iwata T,
Maruyama K, Endo M, Suzuki M. Novel bifunctional probe for radioisotope-free
photoaffinity labeling: compact structure comprised of photospecific ligand
ligation and detectable tag anchoring units. Org Biomol Chem. 2004 Mar
7;2(5):637-41. PubMed PMID: 14985799.

Kasai H, Yao A, Oyama T, Hasegawa H, Akazawa H, Toko H, Nagai T, Kinugawa K,
Kohmoto O, Maruyama K, Takahashi T, Nagai R, Miyawaki A, Komuro I. Direct
measurement of Ca2+ concentration in the SR of living cardiac myocytes. Biochem
Biophys Res Commun. 2004 Feb 20;314(4):1014-20. PubMed PMID: 14751234.

Tanaka M, Maruyama K. Cough reflex induced by microinjection of citric acid
into the larynx of guinea pigs: new coughing model. J Pharmacol Sci. 2003
Dec;93(4):465-70. PubMed PMID: 14737018.

Kume H, Maruyama K, Kametani F. Intracellular domain generation of amyloid
precursor protein by epsilon-cleavage depends on C-terminal fragment by
alpha-secretase cleavage. Int J Mol Med. 2004 Jan;13(1):121-5. PubMed PMID:
14654982.

Inoue R, Tanabe M, Kono K, Maruyama K, Ikemoto T, Endo M. Ca2+-releasing
effect of cerivastatin on the sarcoplasmic reticulum of mouse and rat skeletal
muscle fibers. J Pharmacol Sci. 2003 Nov;93(3):279-88. PubMed PMID: 14646245.

Kume H, Sekijima Y, Maruyama K, Kametani F. gamma-Secretase can cleave
amyloid precursor protein fragments independent of alpha- and beta-secretase
pre-cutting. Int J Mol Med. 2003 Jul;12(1):57-60. PubMed PMID: 12792809.

Asai M, Hattori C, Szabó B, Sasagawa N, Maruyama K, Tanuma S, Ishiura S.
Putative function of ADAM9, ADAM10, and ADAM17 as APP alpha-secretase. Biochem
Biophys Res Commun. 2003 Jan 31;301(1):231-5. PubMed PMID: 12535668.

Saito Y, Tetsuka M, Yue L, Kawamura Y, Maruyama K. Functional role of
N-linked glycosylation on the rat melanin-concentrating hormone receptor 1. FEBS
Lett. 2003 Jan 2;533(1-3):29-34. PubMed PMID: 12505154.

Shirotani K, Tsubuki S, Lee HJ, Maruyama K, Saido TC. Generation of amyloid
beta peptide with pyroglutamate at position 3 in primary cortical neurons.
Neurosci Lett. 2002 Jul 12;327(1):25-8. PubMed PMID: 12098492.

Hattori C, Asai M, Oma Y, Kino Y, Sasagawa N, Saido TC, Maruyama K, Ishiura
S. BACE1 interacts with nicastrin. Biochem Biophys Res Commun. 2002 May
17;293(4):1228-32. PubMed PMID: 12054507.

Shizuka-Ikeda M, Matsubara E, Ikeda M, Kanai M, Tomidokoro Y, Ikeda Y,
Watanabe M, Kawarabayashi T, Harigaya Y, Okamoto K, Maruyama K, Castaño EM, St
George-Hyslop P, Shoji M. Generation of amyloid beta protein from a presenilin-1
and betaAPP complex. Biochem Biophys Res Commun. 2002 Mar 29;292(2):571-8. PubMed PMID: 11906199.

Westerman BA, Poutsma A, Maruyama K, Schrijnemakers HF, van Wijk IJ, Oudejans
CB. The proneural genes NEUROD1 and NEUROD2 are expressed during human
trophoblast invasion. Mech Dev. 2002 Apr;113(1):85-90. PubMed PMID: 11900979.


日本語総説

カテプシンBを介したアミロイド前駆体タンパク質の代謝経路
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加齢性神経変性モデルSAMP10脳における脂質メディエーターの網羅的定量解析
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日本内分泌学会雑誌 87(1): 280-280, 2011.

Angiotennsin converting enzyme inhibitor(ACEI)の心保護作用
相崎良美, 吉河歩, 飯田慎一郎, 加藤誠, 孫驍, 丸山敬, 村松俊裕, 松村誠, 西村重敬, 千本松孝明
日本内分泌学会雑誌 85(2): 724-724, 2009.

既存薬物によるアルツハイマー病への応用
浅井将, 岩田修永, 西道隆臣, 丸山敬
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Angiotensin IIによるJAK2キナーゼを介するPLZFチロシンリン酸化の解析
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オーフアンGPCRとうつ病
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日本薬理学雑誌 127(3): 190-195, 2006.

Kyotorphin has a novel action on rat cardiac muscle
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摂食とメラニン凝集ホルモン(melanin-concentrating hormone:MCH)
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モルモットの喉頭へのクエン酸微量注入による咳誘発モデル
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Alzheimer病モデルマウス
丸山敬
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