・業績:
【原著論文】 Chiaki Itami*, Naofumi Uesaka, Jui-Yen Huang, Hui-Chen Lu, Kenji Sakimura, Masanobu
Kano, Fumitaka Kimura*. Endocannabinoid-dependent formation of columnar
axonal projection in the mouse cerebral cortex. PNAS. 119, 2022
Fumitaka Kimura*, Chiaki Itami. A hypothetical model concerning how spike timing-dependent plasticity
contributes to the neural circuit formation and the initiation of critical
period in barrel cortex. J Neurosci.39,3784-3791, 2019
Minoru Ohshima, Chiaki Itami, Fumitaka Kimura*. The α2A -adrenoceptor suppresses excitatory synaptic
transmission to both excitatory and inhibitory neurons in layer 4 barrel
cortex. J Physiol.595, 6923-6937, 2017
Chiaki Itami*, Fumitaka Kimura*. Concurrently induced plasticity due to convergence
of distinct forms of spike timing-dependent plasticity in the developing
barrel cortex. Eur J Neurosci. 44, 2984-2990, 2016
Chiaki Itami*, Jui-Yen Huang, Miwako Yamasaki, Masahiko Watanabe, Hui-Chen Lu, Fumitaka Kimura*. Developmental Switch in Spike Timing-Dependent Plasticity and Cannabinoid-Dependent Reorganization of the Thalamocortical Projection in the Barrel Cortex. J. Neurosci. 36, 7039-54, 2016
Toshiyuki Mizui, Yasuyuki Ishikawa, Haruko Kumanogoh, Maria Lume, Tomoya
Matsumoto, Tomoko Hara, Tomoko Hara, Shigeto Yamawaki, Masami Takahashi,
Sadao Shiosaka, Chiaki Itami, Koichi Uegaki, Mart Saarma, Masami Kojima*. BDNF pro-peptide actions facilitate hippocampal LTD and are altered by the common BDNF polymorphism Val66Met. PNAS. 112, E3067-74, 2015
Naoki Adachi, Tadahiro Numakawa*, Emi Kumamaru, Chiaki Itami, Shuichi Chiba, Yoshimi Iijima, Misty Richards, Ritsuko Katoh-Semba and
Hiroshi Kunugi*. Phencyclidine-Induced Decrease of Synaptic Connectivity
via Inhibition of BDNF Secretion in Cultured Cortical Neurons. Cereb Cortex.
23:847-58, 2013
Chiaki Itami*, Fumitaka Kimura*. Developmental switch in the spike-timing dependent plasticity contributes to the initiation of the critical period. J. Neurosci. 32, 15000-15011, 2012
Fumitaka Kimura*, Chiaki Itami, Koji Ikezoe, Hiroshi Tamura, Ichiro Fujita, Yuchio Yanagawa, Kunihiko
Obata, Minoru Ohshima. Fast activation of feedforward inhibitory neurons
from thalamic input and its relevance to the regulation of spike sequences
in the barrel cortex. J Physiol. 588, 2769-87, 2010
Fumitaka Kimura* and Chiaki Itami. Myelination and isochronicity in neural networks. Frontiers in Neuroanatomy 3, 2009
Chiaki Itami*, Fumitaka Kimura, Shun Nakamura. Brain-Derived Neurotrophic Factor Regulates
the Maturation of Layer 4 Fast-Spiking Cells after the Second Postnatal
Week in the Developing Barrel Cortex. J. Neurosci. 27, 2241-2252, 2007
Chiaki Itami, Fumitaka Kimura,Tomoko Kohno, Masato Matsuoka, Masumi Ichikawa, Tadaharu Tsumoto, Shun Nakamura*. Brain-derived neurotrophic factor-dependent unmasking of "silent" synapses in the developing mouse barrel cortex. PNAS. 100, 13069-13074, 2003
Keigo Kohara, Akihiko Kitamura, Naoki Adachi, Megumi Nishida, Chiaki Itami, Shun Nakamura, and Tadaharu Tsumoto*. Inhibitory But Not Excitatory Cortical
Neurons Require Presynaptic Brain-Derived Neurotrophic Factor for Dendritic
Development, as Revealed by Chimera Cell Culture. J. Neurosci. 23, 6123-6131,
2003
Salami Mahmoud, Chiaki Itami, Tadaharu Tsumoto and Fumitaka Kimura*.A mechanism of producing constant latency irrespective of distance by extracortical myelination in thalamocortical pathway. PNAS. 100, 6174-6179, 2003
Chiaki Itami, Kazuyuki Samejima, Shun Nakamura*, Improved data processing for optical
imaging of developing neuronal connectivity in the neonatal mouse barrel
cortex. Brain Res Brain Res Protoc 7, 103-14, 2001
Chiaki Itami, Kiyonobu Mizuno, Tomoko Kohno, Shun Nakamura*, Brain-derived neurotrophic factor requirement for activity-dependent maturation of glutamatergic synapse in developing mouse somatosensory cortex. Brain Res. 857, 141-150, 2000.
【講演】 Itami,C., Converging effects on network formation of distinct forms of spike timimg-dependent-plasticities
onto L2/3 pyramidal neurons in barrel cortex. 第39回日本神経科学大会、ミニシンポジウム, 2016年7月20〜22日,
横浜,
【学会活動】 Itami, C, Huang,JY, Lu, HC., Kimura, F. Effects of exogenously administered cannabinoid agonists on axonal projection of layer 4 neurons in the developing mouse barrel cortex, 48th Annual meeting of Society for Neuroscience, 2018年11月3日~7日, San Diego, 米国
Kimura, F., Itami, C., Sakimura, K., Kano, M., The endocannabinoid 2-arachidonoylglycerol is
required for neuronal circuit formation in the developing barrel cortex.
11th FENS Forum of Neuroscience, 2018年7月7日〜11日, Berlin, ドイツ
Itami, C. Sakimura, K. Kano, M., Kimura, F. Physiological and morphological roles
of endocannabinoid 2-arachidonoylglycerol in the developing neuronal circuit
in the mouse barrel cortex. 46th Annual Meeting of Society for Neuroscience,
2016年11月12日〜16日 San Diego, 米国
Kimura, F. Itami, C, Huang,JY, Yamasaki, M., Masahiko, W., Lu, HC. Developmental Switch in
Spike Timing-Dependent Plasticity and Cannabinoid-Dependent Reorganization
of the Thalamocortical Projection in the Barrel Cortex. 10th FENS Forum
of Neuroscience, 2016年7月2日〜6日, Copenhagen, デンマーク
Itami, C, Huang,JY, Lu, HC., Kimura, F. Topographical precision in the thalamocortical projection mediated by cannabinoid receptor in the developing barrel cortex. 44th Annual Meeting of Society for Neuroscience, 2014年11月15日〜19日, Washington, DC., 米国
Itami, C, Huang,JY, Lu, HC., Kimura, F. Cannabinoid receptor mediated spike timing-dependent
plasticity at thalamocortical synapses in the developing mouse barrel cortex.
43th Annual meeting of Society for Neuroscience, 2013年11月9〜13日, San Diego,
米国
Itami, C, Kimura, F. Cooperative heterosynaptic interaction of spike timing-dependent
plasticity in the developing barrel cortex. 42th Annual meeting of Society
for Neuroscience, 2012年10月15日, New Orleans, 米国
Kimura, F., Itami, C. Developmental switch in the spike-timing dependent plasticity contributes to the initiation of the critical period in the barrel cortex. The 8th FENS Forum of Neuroscience, 2012年7月14〜18日, Barcelona, スペイン
Itami, C, Kimura, F. A developmental switch in the spike timing dependent plasticity
coincidently occurring with the initiation of map plasticity in the barrel
cortex. 41th Annual meeting of Society for Neuroscience, 2011年11月12〜16日,
Washington, DC, 米国
Kimura, F., Itami, C. Developmental switch in the spike timing dependent plasticity at layer 4 to layer 2/3 synapses in coincidence with the initiation of critical period in the mouse barrel cortex. 8th IBRO WORLD CONGRESS OF NEUROSCIENCE, 2011年7月14〜18日, イタリア
Itami, C, Y. Yanagawa, Y., H. Kumanogoh, H, Gene expression analysis of inhibitory
cells derived from developing barrel cortex in BDNF knockout mice. 第33回日本分子生物学会年会,
2010年12月7〜12月10日, 神戸
Itami, C., Kimura, F., Characterization of bilateral spike timing dependent plasticity specifically appeared during the 2nd postnatal week at L4-L2/3 synapses in the mouse barrel cortex. 40th Annual meeting of Society for Neuroscience, 2010年11月13〜17日, San Diego, 米国
Itami, C., Kimura, F., Characterization of bilateral spike timing dependent plasticity
specifically appeared during the 2nd postnatal week at L4-L2/3 synapses
in the mouse barrel cortex. BARRELS XXIII, 2010年11月11〜12日, San Diego, 米国
Ohshima, M., Itami, C., Yanagawa, Y., Kimura, F. Activation of α2A adrenoceptors suppresses
excitatory synaptic transmission to layer 4 cells both from thalamic and
intracortical in the mouse barrel cortex through presynaptic mechanism,
39th Annual meeting of Society for Neuroscience, 2009年10月17〜21日, Chicago,
米国
31. Itami,C., Watanabe, S-I., Kimura, F. Developmental switch in the spike-timing-dependent plasticity between L4-L2/3 synapse in parallel with feedforward inhibition in mouse barrel cortex 39th Annual meeting of Society for Neuroscience, 2009年10月17〜21日, Chicago, 米国
Kimura,F., Itami, C., Ikezoe, K., Tamura, H., Fujita, I., Yanagawa, Y., Obata, K., Ohshima,
M. Developmental changes in the fine temporal control of thalamic activation
of cortical cells and associated changes in plasticity. Barrels XXI, 2008年11月13〜14日,
Baltimore, 米国
Itami, C., Kumanogoh, H., Masuda, S., Takeda, S., Obata, K., Yanagawa, Y., Watanabe,
S-I., Nakamura, S. Gene expression analysis of inhibitory cells derived
from developing barrel cortex in BDNF knockout mice. 37thAnnual Meeting
of Neuroscience, 2007年11月3〜7日, San Diego, 米国
Kimura, F. Itami, C., Ikezoe, K., Tamura, H., Fujita, I. Obata, K., Yanagawa, Y., Ohshima, M. Prior activation of GABAergic neurons to excitatory neurons by thalamic axons within a single barrel in the mouse thalamocortical system: relevance to the spike timing dependent plasticity. 37thAnnual Meeting of Neuroscience, 2007年11月3〜7日, San Diego, 米国
Kimura, F. Itami, C., Obata, K., Yanagawa, Y., Ohshima, Thalamic activation of GABAergic neurons
leads to that of excitatory neurons within a single barrel in the mouse
thalamocortical system. IBRO World congress of Neuroscience, 2007年7月12〜17日,
Melbourne, オーストラリア
Itami, C., Kimura, F., Nakamura, S. BDNF regulates the maturation of layer 4 fast spiking cells after the 2nd postnatal week in the developing barrel cortex. IBRO World congress of Neuroscience, 2007年7月12〜17日, Melbourne, オーストラリア
Kimura F, Itami C, Obata K, Yanagawa Y, Precedent activation of GABAergic neurons to excitatory
cells within a barrel by thalamic input in mouse thalamocortical slices,
35thAnnual Meeting of Neuroscienc, Washington, DC, 2005. (一般発表)
Itami C, Kimura F, BDNF controls functional differentiation of GABAergic interneurons
innervated by thalamic input during cortical development, 35thAnnual Meeting
of Neuroscienc, Washington, DC, 2005. (一般発表)
Itami C, Nakamura S, BDNF affects intrinsic properties of layer 4 neurons in mice
barrel cortex during cortical development. 34thAnnual Meeting of Neuroscienc,
San Diego, 2004. (一般発表)
Kimura F, Itami C, Kameyama, Tsumoto T, Nicotinic activation induced an enhancement followed by layer specific suppression in thalamocortical transmission studied in mouse barrel cortex, 34thAnnual Meeting of Neuroscienc, San Diego, 2004. (一般発表)
木村文隆、Mahmoud Salami、伊丹千晶、津本忠治、Constant conduction time between thalamus and cortex due to change
of conduction velocity resulting from regional myelination、第26回日本神経科学大会、名古屋、2003.
(一般発表)
伊丹千晶、木村文隆、津本忠治、中村俊、BDNF regulates activation of postsynaptically silent synapses
in developing mouse barrel cortex、第26回日本神経科学大会、名古屋、2003. (一般発表)
Itami C, Yokosuka M, Sahara Y, Tabira T, Nakamura S, Developmental regulation
of dendritic spine morphology in cortical neurons by presenilin-1. 33thAnnual
Meeting of Neuroscienc, New Orleans, 2003. (一般発表)
Kimura F, Salami M, Itami C, Tsumoto T, Constant conduction time between thalamus and cortex due to
change of conduction velocity resulting from regional myelination, 6th
IBRO World Congress of Neuroscience, Prague, 2003. (一般発表)
Itami C, Kimura F, Tsumoto T, Nakamura S, BDNF regulates activation of postsynaptically silent synapses in developing mouse barrel cortex, 6th IBRO World Congress of Neuroscience, Prague, 2003. (一般発表)
Kimura F, Salami M, Itami C, Tsumoto T, Distance-independent constant latency yielded by a change of conduction velocity due to selective myelination from thalamus to white matter, 32thAnnual Meeting of Neuroscience, Orlando, 2002. (一般発表)
Itami C, Kimura F, Tsumoto T, Nakamura S, BDNF regulates activation of silent
synapse in developing mouse barrel cortex. 32thAnnual Meeting of Neuroscience,
32thAnnual Meeting of Neuroscience, Orlando, 2002. (一般発表)
Kimura F, Salami M, Itami C, Tsumoto T, Developmental changes in the conduction velocity of thalamocortical
pathway in the mouse somatosensory system, 31thAnnual Meeting of Neuroscience,
San Diego, 2001. (一般発表)
Itami C, Kimura F, Tsumoto T, Nakamura S, BDNF regulates activation of silent synapse in developing mouse barrel cortex. 31thAnnual Meeting of Neuroscience, San Diego, 2001. (一般発表)
Tumoto T, Takada N, Kohara K, Itami C, Nakamura S, Different actions of brain-derived neurotrophic factor on
NMDA and AMPA receptors cultured cortical neurons. 11th Neuropharmacology
Coference: Molecular Mechanisms of Synaptic Function, San Diego, 2001.
(一般発表)
Itami C, Kimura F, Tsumoto T, Nakamur, S, Involvement of BDNF in activating silent
synapses during postnatal development of mouse cortex. 30hAnnual Meeting
of Neuroscience, New Orleans, 2000. (一般発表)