Member

• 講師　　平沢　統
  
  
  
  ・略歴：
  
  2001年　筑波大学大学院生物科学研究科　生物物理化学専攻　単位取得退学
  2001年　慶應義塾大学医学部生理学 助手
  　　　　　博士（理学）取得
  2003年　Postdoctoral Fellow, Department of Neurobiology, Harvard Medical School
  2010年　理化学研究所　脳科学総合研究センター 研究員
  2012年　自然科学研究機構　生理学研究所　研究員
  2014年　埼玉医科大学医学部生理学　助教
  2023年　埼玉医科大学医学部生理学　講師
  
  
  ・専門：
  
  網膜の神経生理学
  
  ・研究テーマ：
  
  癌細胞の転移能調節機構の解析
  
  癌細胞膜の電気生理学的特性の解析
  
  視覚情報処理における網膜抑制性回路の役割の解明
  
  ・業績：
  Araki T, Nagashima M, Hirasawa H, Tamalu F, Katagiri Y, Miwa N*.
  Epigenome-wide association analysis of pancreatic exocrine cells from high-fat- and normal diet-fed mice and its potential use for understanding the oncogenesis of human pancreatic cancer. Biochem Biophys Res Commun 637:50-57 (2022)
  
  Saito R, Satoh H, Aoba K, Hirasawa H, Miwa N*.
  Dicalcin suppresses in vitro trophoblast attachment in human cell lines. Biochem Biophys Res Commun 570: 206-213 (2021)
  
  Hirasawa H., Miwa N., Watanabe, S.-I. GABAergic and glycinergic systems regulate ON-OFF electroretinogram by cooperatively modulating cone pathways in the amphibian retina . Eur J Neurosci. 53(5):1428-1440 (2021) doi: 10.1111/ejn.15054. Epub 2020 Dec 3. 
  
  Nagashima M, Miwa N*, Hirasawa H, Katagiri Y*, Takamatsu K, Morita M.
  Genome-wide DNA methylation analysis in obese women predicts an epigenetic signature for future endometrial cancer. Sci Rep 9: 6469 (2019)
  
  Hirasawa H., Contini M. and Raviola E. Extrasynaptic release of GABA and dopamine by retinal dopaminergic neurons. (Review article) Philos. Trans. R. Soc. Lond. B. Biol. Sci. 5: 370(1672). (2015)
  

  Hirasawa H., Betensky R. and Raviola E. Co-release of dopamine and GABA by a retinal dopaminergic neuron. Journal of Neuroscience: 32: 13281-13291. (2012) 
  
  Hirasawa H., Yamada M. and Kaneko A. Acidification of the synaptic cleft of cone photoreceptor terminal controls the amount of transmitter release, thereby forming the receptive field surround in the vertebrate retina. (Review article) Journal of Physiological Sciences 62:359-375. (2012)
  
  Kamiji NL, Yamamoto K, Hirasawa H, Yamada M, Usui S, Kurokawa M. Proton feedback mediates the cascade of color-opponent signals onto H3 horizontal cells in goldfish retina. Neuroscience Research 72:306-315. (2012) 
  
  Hirasawa H., Puopolo M. and Raviola E. Extrasynaptic release of GABA by retinal dopaminergic neurons. Journal of Neurophysiology 102:146-158. (2009) 
  
  Dorenbos R., Contini M., Hirasawa H., Gustincich S. and  Raviola E. Expression of circadian clock genes in retinal dopaminergic cells.Visual Neuroscience 24:573-580. (2007) 
  
  Tatsukawa T., Hirasawa H., Kaneko A. and Kaneda M. GABA-mediated component in the feedback response of turtle retinal cones. Visual Neuroscience 22:317-324. (2005)
  
   Hirasawa H. and Kaneko A. pH changes in the invaginating synaptic cleft mediate feedback from horizontal cells to cone photoreceptors by modulating Ca channels. Journal of General Physiology 122: 657-671. (2003)
  
  Hirasawa H., Shiells R.A. and Yamada M. A metabotropic glutamate receptor regulates transmitter release from cone presynaptic terminals in carp retinal slices. Journal of General Physiology 119:55-68. (2002)
  
  Hirasawa H., Shiells R.A. and Yamada M. Blocking AMPA receptor desensitization prolongs spontaneous EPSC decay times and depolarizes H1 horizontal cells in carp retinal slices. Neuroscience Research 40:217-225. (2001)
  
  Hirasawa H., Shiells R.A. and Yamada M. Analysis of spontaneous EPSCs in retinal horizontal cells of the carp. Neuroscience Research 40:75-86. (2001)
  
  
  ・連絡先：
  hhirasa(at)saitama-med.ac.jp
  
  電話：049-276-1152 （内2083）